Telomere-associated protein RIF1

Telomere-associated protein RIF1 is a protein that in humans is encoded by the RIF1 gene.^[5][6][7]

AliasesRIF1, replication timing regulatory factor 1

External IDsOMIM: 608952; MGI: 1098622; HomoloGene: 41231; GeneCards: RIF1; OMA:RIF1 - orthologs

Chr.Chromosome 2 (human)^[1]

End151,508,013 bp^[1]

Quick facts RIF1, Identifiers ...

RIF1
Identifiers
Aliases	RIF1, replication timing regulatory factor 1
External IDs	OMIM: 608952; MGI: 1098622; HomoloGene: 41231; GeneCards: RIF1; OMA:RIF1 - orthologs
Gene location (Human) Chr. Chromosome 2 (human)[1] Band 2q23.3 Start 151,409,883 bp[1] End 151,508,013 bp[1]
Gene location (Mouse) Chr. Chromosome 2 (mouse)[2] Band 2 C1.1|2 29.98 cM Start 51,962,844 bp[2] End 52,012,395 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in buccal mucosa cell gastrocnemius muscle muscle of thigh Achilles tendon testicle secondary oocyte Skeletal muscle tissue of rectus abdominis corpus callosum internal globus pallidus gonad Top expressed in spermatocyte zygote secondary oocyte primary oocyte primitive streak cumulus cell epiblast Gonadal ridge spermatid abdominal wall More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding Cellular component cytoplasm telomere plasma membrane spindle male pronucleus female pronucleus nucleus cytoskeleton nucleoplasm chromosome condensed chromosome nuclear body nuclear membrane spindle midzone site of double-strand break Biological process stem cell population maintenance cell cycle double-strand break repair via nonhomologous end joining negative regulation of transcription by RNA polymerase II telomere maintenance telomere maintenance in response to DNA damage positive regulation of histone H3-K9 methylation cellular response to DNA damage stimulus positive regulation of isotype switching negative regulation of double-strand break repair via homologous recombination positive regulation of double-strand break repair via nonhomologous end joining DNA repair cellular response to leukemia inhibitory factor Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 55183 51869 Ensembl ENSG00000080345 ENSMUSG00000036202 UniProt Q5UIP0 Q6PR54 RefSeq (mRNA) NM_001177663 NM_001177664 NM_001177665 NM_018151 NM_175238 NM_001355414 NM_001355415 RefSeq (protein) NP_001171134 NP_001171135 NP_001171136 NP_060621 NP_780447 NP_001342343 NP_001342344 Location (UCSC) Chr 2: 151.41 – 151.51 Mb Chr 2: 51.96 – 52.01 Mb PubMed search [3] [4]
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RIF1 and RIF2 cap the chromosome ends (telomeres) in yeast.^[8] In higher eukaryotes, Rif1 is involved in DNA damage response, organisation of chromatin architecture and the regulation of replication timing. RIF1 has been shown to bind to RNA in the nucleus.^[9]