RIPK4

Receptor-interacting serine/threonine-protein kinase 4 is an enzyme that in humans is encoded by the RIPK4 gene.^[5][6]

AliasesRIPK4, ANKK2, ANKRD3, DIK, NKRD3, PKK, PPS2, RIP4, receptor interacting serine/threonine kinase 4, CHANDS

External IDsOMIM: 605706; MGI: 1919638; HomoloGene: 10772; GeneCards: RIPK4; OMA:RIPK4 - orthologs

Chr.Chromosome 21 (human)^[1]

End41,767,089 bp^[1]

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RIPK4
Identifiers
Aliases	RIPK4, ANKK2, ANKRD3, DIK, NKRD3, PKK, PPS2, RIP4, receptor interacting serine/threonine kinase 4, CHANDS
External IDs	OMIM: 605706; MGI: 1919638; HomoloGene: 10772; GeneCards: RIPK4; OMA:RIPK4 - orthologs
Gene location (Human) Chr. Chromosome 21 (human)[1] Band 21q22.3 Start 41,739,369 bp[1] End 41,767,089 bp[1]
Gene location (Mouse) Chr. Chromosome 16 (mouse)[2] Band 16|16 C4 Start 97,543,133 bp[2] End 97,564,987 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in gingival epithelium palpebral conjunctiva oral cavity amniotic fluid epithelium of bronchus mucosa of paranasal sinus nasal epithelium bronchial epithelial cell mucosa of pharynx kidney tubule Top expressed in transitional epithelium of urinary bladder conjunctival fornix hair follicle seminal vesicula skin of external ear skin of abdomen skin of back epithelium of small intestine cornea vestibular membrane of cochlear duct More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein serine/threonine kinase activity ATP binding kinase activity nucleotide binding protein kinase activity transferase activity protein binding Cellular component membrane cytoplasm Biological process protein phosphorylation morphogenesis of an epithelium positive regulation of NF-kappaB transcription factor activity phosphorylation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 54101 72388 Ensembl ENSG00000183421 ENSMUSG00000005251 UniProt P57078 Q9ERK0 RefSeq (mRNA) NM_020639 NM_023663 RefSeq (protein) n/a NP_076152 Location (UCSC) Chr 21: 41.74 – 41.77 Mb Chr 16: 97.54 – 97.56 Mb PubMed search [3] [4]
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The protein encoded by this gene is a serine/threonine protein kinase that interacts with protein kinase C-delta. The encoded protein can also activate NFkappaB and is required for keratinocyte differentiation. This kinase undergoes autophosphorylation.^[6]