RNF111
Protein-coding gene in the species Homo sapiens
From Wikipedia, the free encyclopedia
E3 ubiquitin-protein ligase Arkadia is an enzyme that in humans is encoded by the RNF111 gene.[5][6]
Function
The protein encoded by this gene contains a RING finger domain, a motif known to be involved in protein-protein and protein-DNA interactions. The mouse counterpart of this gene (Rnf111/arkadia) has been shown to genetically interact with the transforming growth factor (TGF) beta-like factor Nodal, and act as a modulator of the nodal signaling cascade, which is essential for the induction of mesoderm during embryonic development.[6]
Interactions
RNF111 has been shown to interact with Mothers against decapentaplegic homolog 7[7] and Mothers against decapentaplegic homolog 3.[7][8]
