RNF20

E3 ubiquitin-protein ligase BRE1A is an enzyme that in humans is encoded by the RNF20 gene.^{[5][6][7][8][9]}

AliasesRNF20, BRE1, BRE1A, hBRE1, ring finger protein 20

External IDsOMIM: 607699; MGI: 1925927; HomoloGene: 5571; GeneCards: RNF20; OMA:RNF20 - orthologs

Chr.Chromosome 9 (human)^[1]

End101,563,344 bp^[1]

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RNF20
Identifiers
Aliases	RNF20, BRE1, BRE1A, hBRE1, ring finger protein 20
External IDs	OMIM: 607699; MGI: 1925927; HomoloGene: 5571; GeneCards: RNF20; OMA:RNF20 - orthologs
Gene location (Human) Chr. Chromosome 9 (human)[1] Band 9q31.1 Start 101,533,853 bp[1] End 101,563,344 bp[1]
Gene location (Mouse) Chr. Chromosome 4 (mouse)[2] Band 4|4 B1 Start 49,632,006 bp[2] End 49,656,887 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in tibialis anterior muscle cardiac muscle tissue of right atrium myocardium of left ventricle mucosa of ileum deltoid muscle caput epididymis bronchial epithelial cell parietal pleura retinal pigment epithelium corpus callosum Top expressed in tail of embryo genital tubercle blood neural layer of retina seminal vesicula secondary oocyte zygote granulocyte maxillary prominence renal corpuscle More reference expression data BioGPS More reference expression data
Gene ontology Molecular function transcription coactivator activity histone binding p53 binding chromatin binding metal ion binding mRNA 3'-UTR binding protein binding ubiquitin protein ligase binding transferase activity ubiquitin-protein transferase activity Cellular component ubiquitin ligase complex HULC complex nucleolus nucleus nucleoplasm Biological process regulation of transcription, DNA-templated negative regulation of mRNA polyadenylation positive regulation of histone methylation ubiquitin-dependent protein catabolic process protein polyubiquitination positive regulation of transcription, DNA-templated negative regulation of cell migration regulation of mitotic cell cycle histone H2B ubiquitination positive regulation of histone H2B ubiquitination histone ubiquitination protein ubiquitination histone monoubiquitination chromatin organization Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 56254 109331 Ensembl ENSG00000155827 ENSMUSG00000028309 UniProt Q5VTR2 Q5DTM8 RefSeq (mRNA) NM_019592 NM_001163263 NM_182999 NM_001356401 RefSeq (protein) NP_062538 NP_001156735 NP_892044 NP_001343330 Location (UCSC) Chr 9: 101.53 – 101.56 Mb Chr 4: 49.63 – 49.66 Mb PubMed search [3] [4]
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The protein encoded by this gene shares similarity with BRE1 of S. cerevisiae. Yeast BRE1 is a ubiquitin ligase required for the ubiquitination of histone H2B and the methylation of histone H3.^[9]