RNF40

Protein-coding gene in the species Homo sapiens From Wikipedia, the free encyclopedia

E3 ubiquitin-protein ligase BRE1B is an enzyme that in humans is encoded by the RNF40 gene.[5][6][7][8]

AliasesRNF40, BRE1B, RBP95, STARING, ring finger protein 40
End30,776,307 bp[1]
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RNF40
Identifiers
AliasesRNF40, BRE1B, RBP95, STARING, ring finger protein 40
External IDsOMIM: 607700; MGI: 2142048; HomoloGene: 8856; GeneCards: RNF40; OMA:RNF40 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001207033
NM_001207034
NM_001286572
NM_014771
NM_194352

NM_172281
NM_001360883

RefSeq (protein)

NP_001193962
NP_001193963
NP_001273501
NP_055586

NP_758485
NP_001347812

Location (UCSC)Chr 16: 30.76 – 30.78 MbChr 7: 127.19 – 127.2 Mb
PubMed search[3][4]
Wikidata
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Function

The protein encoded by this gene contains a RING finger, a motif known to be involved in protein-protein and protein-DNA interactions. This protein was reported to interact with the tumor suppressor protein RB1. Studies of the rat counterpart suggested that this protein may function as an E3 ubiquitin-protein ligase, and facilitate the ubiquitination and degradation of syntaxin 1, which is an essential component of the neurotransmitter release machinery.[8]

Interactions

RNF40 has been shown to interact with STX1A.[7]

References

Further reading

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