RNF40
Protein-coding gene in the species Homo sapiens
From Wikipedia, the free encyclopedia
E3 ubiquitin-protein ligase BRE1B is an enzyme that in humans is encoded by the RNF40 gene.[5][6][7][8]
External IDsOMIM: 607700; MGI: 2142048; HomoloGene: 8856; GeneCards: RNF40; OMA:RNF40 - orthologs
Function
The protein encoded by this gene contains a RING finger, a motif known to be involved in protein-protein and protein-DNA interactions. This protein was reported to interact with the tumor suppressor protein RB1. Studies of the rat counterpart suggested that this protein may function as an E3 ubiquitin-protein ligase, and facilitate the ubiquitination and degradation of syntaxin 1, which is an essential component of the neurotransmitter release machinery.[8]