ROM1

Rod outer segment membrane protein 1 is a protein that in humans is encoded by the ROM1 gene.^[5][6]

AliasesROM1, ROM, ROSP1, RP7, TSPAN23, retinal outer segment membrane protein 1

External IDsOMIM: 180721; MGI: 97998; HomoloGene: 276; GeneCards: ROM1; OMA:ROM1 - orthologs

Chr.Chromosome 11 (human)^[1]

End62,615,116 bp^[1]

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ROM1
Identifiers
Aliases	ROM1, ROM, ROSP1, RP7, TSPAN23, retinal outer segment membrane protein 1
External IDs	OMIM: 180721; MGI: 97998; HomoloGene: 276; GeneCards: ROM1; OMA:ROM1 - orthologs
Gene location (Human) Chr. Chromosome 11 (human)[1] Band 11q12.3 Start 62,611,722 bp[1] End 62,615,116 bp[1]
Gene location (Mouse) Chr. Chromosome 19 (mouse)[2] Band 19 A|19 6.03 cM Start 8,904,755 bp[2] End 8,906,720 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in gonad C1 segment amygdala putamen caudate nucleus nucleus accumbens cingulate gyrus anterior cingulate cortex Descending thoracic aorta right frontal lobe Top expressed in neural layer of retina retinal pigment epithelium epithelium of lens pineal gland corneal stroma calvaria interventricular septum body of femur muscle of thigh myocardium of ventricle More reference expression data BioGPS More reference expression data
Orthologs Species Human Mouse Entrez 6094 19881 Ensembl ENSG00000149489 ENSMUSG00000071648 UniProt Q03395 P32958 RefSeq (mRNA) NM_000327 NM_009073 RefSeq (protein) NP_000318 NP_033099 Location (UCSC) Chr 11: 62.61 – 62.62 Mb Chr 19: 8.9 – 8.91 Mb PubMed search [3] [4]
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This gene is a member of a photoreceptor-specific gene family and encodes an integral membrane protein found in the photoreceptor disk rim of the eye. This protein can form homodimers or can heterodimerize with another photoreceptor protein, peripherin-2 (PRPH2; retinal degeneration, slow; RDS). It is essential for disk morphogenesis, and may also function as an adhesion molecule involved in the stabilization and compaction of outer segment disks or in the maintenance of the curvature of the rim. Certain defects in this gene have been associated with the degenerative eye disease retinitis pigmentosa.^[6]