60S ribosomal protein L35a

60S ribosomal protein L35a is a protein that in humans is encoded by the RPL35A gene.^[5][6][7]

PDBOrtholog search: PDBe RCSB

AliasesRPL35A, DBA5, L35A, ribosomal protein L35a, eL33

External IDsOMIM: 180468; MGI: 1928894; HomoloGene: 129020; GeneCards: RPL35A; OMA:RPL35A - orthologs

Chr.Chromosome 3 (human)^[1]

Quick facts RPL35A, Available structures ...

RPL35A
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4UG0, 4V6X, 5AJ0, 3J92, 4UJC, 3J7P, 4UJE, 3J7Q, 3J7R, 4D67, 4UJD, 4D5Y, 3J7O
Identifiers
Aliases	RPL35A, DBA5, L35A, ribosomal protein L35a, eL33
External IDs	OMIM: 180468; MGI: 1928894; HomoloGene: 129020; GeneCards: RPL35A; OMA:RPL35A - orthologs
Gene location (Human) Chr. Chromosome 3 (human)[1] Band 3q29 Start 197,950,190 bp[1] End 197,956,610 bp[1]
Gene location (Mouse) Chr. Chromosome 16 (mouse)[2] Band 16|16 B3 Start 32,876,823 bp[2] End 32,880,559 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in tendon of biceps brachii left ovary skin of hip right ovary ganglionic eminence canal of the cervix endothelial cell monocyte right uterine tube body of uterus Top expressed in thymus lens spleen yolk sac ventricular zone lip bone marrow ileum uterus embryo More reference expression data BioGPS n/a
Gene ontology Molecular function protein binding tRNA binding RNA binding structural constituent of ribosome Cellular component cytosol ribosome membrane intracellular anatomical structure cytosolic large ribosomal subunit extracellular exosome extracellular matrix Biological process viral transcription SRP-dependent cotranslational protein targeting to membrane ribosomal large subunit biogenesis translational initiation nuclear-transcribed mRNA catabolic process, nonsense-mediated decay protein biosynthesis rRNA processing cytoplasmic translation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 6165 57808 Ensembl ENSG00000182899 ENSMUSG00000060636 UniProt P18077 O55142 RefSeq (mRNA) NM_000996 NM_001316311 NM_001130484 NM_001130485 NM_021338 RefSeq (protein) NP_000987 NP_001303240 NP_001123956 NP_001123957 NP_067313 Location (UCSC) Chr 3: 197.95 – 197.96 Mb Chr 16: 32.88 – 32.88 Mb PubMed search [3] [4]
Wikidata
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Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein belongs to the L35AE family of ribosomal proteins. It is located in the cytoplasm. The rat protein has been shown to bind to both initiator and elongator tRNAs, and thus, it is located at the P site, or P and A sites, of the ribosome. Although this gene was originally mapped to chromosome 18, it has been established that it is located at 3q29-qter. Transcript variants utilizing alternative transcription initiation sites and alternative polyA signals exist. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome.^[7]