60S acidic ribosomal protein P0

60S acidic ribosomal protein P0 is a protein that in humans is encoded by the RPLP0 gene.^[5][6]

PDBOrtholog search: PDBe RCSB

AliasesRPLP0, L10E, LP0, P0, PRLP0, RPP0, ribosomal protein lateral stalk subunit P0

External IDsOMIM: 180510; MGI: 1927636; HomoloGene: 6517; GeneCards: RPLP0; OMA:RPLP0 - orthologs

Chr.Chromosome 12 (human)^[1]

Quick facts RPLP0, Available structures ...

RPLP0
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4V6X, 5AJ0, 3J92, 4V5Z,%%s4V5Z, 5AJ0, 4V6X, 3J92
Identifiers
Aliases	RPLP0, L10E, LP0, P0, PRLP0, RPP0, ribosomal protein lateral stalk subunit P0
External IDs	OMIM: 180510; MGI: 1927636; HomoloGene: 6517; GeneCards: RPLP0; OMA:RPLP0 - orthologs
Gene location (Human) Chr. Chromosome 12 (human)[1] Band 12q24.23 Start 120,196,699 bp[1] End 120,201,235 bp[1]
Gene location (Mouse) Chr. Chromosome 5 (mouse)[2] Band 5|5 F Start 115,697,526 bp[2] End 115,701,786 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in gonad stromal cell of endometrium ventricular zone mucosa of esophagus skin of leg islet of Langerhans ganglionic eminence right uterine tube skin of abdomen right ovary Top expressed in epiblast ventricular zone embryo lip embryo ganglionic eminence zone of skin esophagus urinary bladder lens More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding structural constituent of ribosome RNA binding large ribosomal subunit rRNA binding peptide binding Cellular component ribosome focal adhesion intracellular anatomical structure cytoplasmic ribonucleoprotein granule cytosolic large ribosomal subunit extracellular exosome cytoplasm nucleus endoplasmic reticulum cytosol membrane postsynaptic density postsynapse ribonucleoprotein complex dendrite synapse Biological process ribosome biogenesis viral transcription SRP-dependent cotranslational protein targeting to membrane translational initiation nuclear-transcribed mRNA catabolic process, nonsense-mediated decay protein biosynthesis rRNA processing viral process interleukin-12-mediated signaling pathway ribosomal large subunit assembly cytoplasmic translation lactation response to selenium ion cellular response to cAMP cellular response to interleukin-4 cellular response to Thyroid stimulating hormone cellular response to phorbol 13-acetate 12-myristate Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 6175 11837 Ensembl ENSG00000089157 ENSMUSG00000067274 UniProt P05388 P14869 RefSeq (mRNA) NM_053275 NM_001002 NM_007475 RefSeq (protein) NP_000993 NP_444505 NP_000993.1 NP_444505.1 NP_031501 Location (UCSC) Chr 12: 120.2 – 120.2 Mb Chr 5: 115.7 – 115.7 Mb PubMed search [3] [4]
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Ribosomes catalyze protein synthesis and consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein, which is the functional equivalent of the E. coli L10 ribosomal protein, belongs to the L10P family of ribosomal proteins. It is a neutral phosphoprotein with a C-terminal end that is nearly identical to the C-terminal ends of the acidic ribosomal phosphoproteins P1 and P2. The P0 protein can interact with P1 and P2 to form a pentameric complex consisting of P1 and P2 dimers, and a P0 monomer. The protein is located in the cytoplasm. Transcript variants derived from alternative splicing exist; they encode the same protein. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome.^[6]