RPN1

Dolichyl-diphosphooligosaccharide—protein glycosyltransferase subunit 1 is an enzyme that in humans is encoded by the RPN1 gene.^[5]

AliasesRPN1, OST1, RBPH1, ribophorin I

External IDsOMIM: 180470; MGI: 98084; HomoloGene: 2213; GeneCards: RPN1; OMA:RPN1 - orthologs

Chr.Chromosome 3 (human)^[1]

End128,681,075 bp^[1]

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RPN1
Identifiers
Aliases	RPN1, OST1, RBPH1, ribophorin I
External IDs	OMIM: 180470; MGI: 98084; HomoloGene: 2213; GeneCards: RPN1; OMA:RPN1 - orthologs
Gene location (Human) Chr. Chromosome 3 (human)[1] Band 3q21.3 Start 128,619,969 bp[1] End 128,681,075 bp[1]
Gene location (Mouse) Chr. Chromosome 6 (mouse)[2] Band 6 D1|6 39.13 cM Start 88,061,464 bp[2] End 88,082,286 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in stromal cell of endometrium corpus epididymis rectum upper lobe of left lung olfactory zone of nasal mucosa right lung right lobe of thyroid gland islet of Langerhans gallbladder body of pancreas Top expressed in medullary collecting duct renal corpuscle seminal vesicula lacrimal gland condyle fossa supraoptic nucleus crypt of lieberkuhn of small intestine spermatocyte secretory cell More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding dolichyl-diphosphooligosaccharide-protein glycotransferase activity RNA binding Cellular component melanosome integral component of membrane oligosaccharyltransferase complex rough endoplasmic reticulum endoplasmic reticulum membrane membrane extracellular matrix endoplasmic reticulum cytosol Biological process protein glycosylation protein N-linked glycosylation via asparagine Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 6184 103963 Ensembl ENSG00000163902 ENSMUSG00000030062 UniProt P04843 Q91YQ5 RefSeq (mRNA) NM_002950 NM_133933 RefSeq (protein) NP_002941 NP_598694 Location (UCSC) Chr 3: 128.62 – 128.68 Mb Chr 6: 88.06 – 88.08 Mb PubMed search [3] [4]
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This gene encodes a type I integral ribophorin membrane protein found only in the rough endoplasmic reticulum. The encoded protein is part of an N-oligosaccharyl transferase complex that links high mannose oligosaccharides to asparagine residues found in the Asn-X-Ser/Thr consensus motif of nascent polypeptide chains. This protein should not be confused with RPN1 of yeast, Drosophila, and C. elegans, which forms part of the regulatory subunit of the 26S proteasome and may mediate binding of ubiquitin-like domains to this proteasome. The human version of this proteasome subunit is PSMD2.^[5]