40S ribosomal protein S25
Protein-coding gene in the species Homo sapiens
From Wikipedia, the free encyclopedia
40S ribosomal protein S25 (eS25) is a protein that in humans is encoded by the RPS25 gene.[5][6]
| RPS25 | |||||||||||||||||||||||||||||||||||||||||||||||||||
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| Aliases | RPS25, S25, ribosomal protein S25 | ||||||||||||||||||||||||||||||||||||||||||||||||||
| External IDs | OMIM: 180465; MGI: 1922867; HomoloGene: 133893; GeneCards: RPS25; OMA:RPS25 - orthologs | ||||||||||||||||||||||||||||||||||||||||||||||||||
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Ribosomes are cellular macromolecules that catalyze protein synthesis across all kingdoms of life. The eukaryotic ribosome consists of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 distinct proteins. The RPS25 gene encodes the eukaryote-specific ribosomal protein eS25 that is a component of the 40S subunit. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome.[6]
Interactions
Besides the interactions that position eS25 at its location in the E site region of the 40S ribosomal subunit, eS25 has been suggested to interact with other cellular proteins. One study has found that eS25 interacts with MDM2 as part of a regulatory feedback loop that stabilizes p53.[7] Additionally, eS25 has been shown to interact with CDC5L.[8]
Function
As a ribosomal protein, eS25 likely plays a role in general protein synthesis; however, the RPS25 gene is non-essential for cellular viability in budding yeast and in select mammalian cell lines, implying that it is not essential for eukaryotic protein synthesis.[9][10] Studies have implicated eS25 in the control of several specialized forms of translation, including that mediated by viral IRESs.[11][12]
