RPS6KB2

Ribosomal protein S6 kinase beta-2 is an enzyme that in humans is encoded by the RPS6KB2 gene.^[4][5][6]

AliasesRPS6KB2, KLS, P70-beta, P70-beta-1, P70-beta-2, S6K-beta2, S6K2, SRK, STK14B, p70(S6K)-beta, p70S6Kb, ribosomal protein S6 kinase B2, S6KB, S6KI(2), S6Kbeta

External IDsOMIM: 608939; MGI: 1927343; HomoloGene: 68374; GeneCards: RPS6KB2; OMA:RPS6KB2 - orthologs

Chr.Chromosome 11 (human)^[1]

End67,435,401 bp^[1]

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RPS6KB2
Identifiers
Aliases	RPS6KB2, KLS, P70-beta, P70-beta-1, P70-beta-2, S6K-beta2, S6K2, SRK, STK14B, p70(S6K)-beta, p70S6Kb, ribosomal protein S6 kinase B2, S6KB, S6KI(2), S6Kbeta
External IDs	OMIM: 608939; MGI: 1927343; HomoloGene: 68374; GeneCards: RPS6KB2; OMA:RPS6KB2 - orthologs
Gene location (Human) Chr. Chromosome 11 (human)[1] Band 11q13.2 Start 67,428,460 bp[1] End 67,435,401 bp[1]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in skin of leg skin of abdomen granulocyte body of stomach apex of heart right lobe of liver right hemisphere of cerebellum anterior pituitary muscle of thigh mucosa of transverse colon n/a More reference expression data BioGPS More reference expression data
Gene ontology Molecular function transferase activity protein kinase activity nucleotide binding peptide binding kinase activity protein serine/threonine kinase activity ATP binding ribosomal protein S6 kinase activity Cellular component cytoplasm nucleoplasm nucleus Biological process intracellular signal transduction protein biosynthesis phosphorylation protein phosphorylation positive regulation of translational initiation signal transduction protein kinase B signaling TOR signaling Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 6199 58988 Ensembl ENSG00000175634 ENSMUSG00000024830 UniProt Q9UBS0 Q9Z1M4 RefSeq (mRNA) NM_001007071 NM_003952 NM_021485 RefSeq (protein) NP_003943 NP_067460.1 Location (UCSC) Chr 11: 67.43 – 67.44 Mb n/a PubMed search [2] [3]
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This gene encodes a member of the RSK (ribosomal S6 kinase) family of serine/threonine kinases. This kinase contains two nonidentical kinase catalytic domains and phosphorylates the S6 ribosomal protein and eucaryotic translation initiation factor 4B (eIF4B). Phosphorylation of S6 leads to an increase in protein synthesis and cell proliferation.^[6]