40S ribosomal protein S7

40S ribosomal protein S7 is a protein that in humans is encoded by the RPS7 gene.^[5][6][7]

PDBOrtholog search: PDBe RCSB

AliasesRPS7, DBA8, S7, ribosomal protein S7, eS7

External IDsOMIM: 603658; MGI: 1333818; HomoloGene: 107159; GeneCards: RPS7; OMA:RPS7 - orthologs

Chr.Chromosome 2 (human)^[1]

Quick facts RPS7, Available structures ...

RPS7
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4UG0, 4V6X, 5A2Q, 5AJ0, 3J7P, 4KZX, 4UJE, 4KZY, 4D5L, 4KZZ, 3J7R, 4UJD, 5FLX, 4D61, 4UJC
Identifiers
Aliases	RPS7, DBA8, S7, ribosomal protein S7, eS7
External IDs	OMIM: 603658; MGI: 1333818; HomoloGene: 107159; GeneCards: RPS7; OMA:RPS7 - orthologs
Gene location (Human) Chr. Chromosome 2 (human)[1] Band 2p25.3 Start 3,575,260 bp[1] End 3,580,920 bp[1]
Gene location (Mouse) Chr. Chromosome 12 (mouse)[2] Band 12|12 A2 Start 28,680,853 bp[2] End 28,685,952 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in gonad left ovary granulocyte ventricular zone islet of Langerhans right ovary rectum lymph node smooth muscle tissue ganglionic eminence Top expressed in ganglionic eminence ventricular zone lens lip yolk sac thymus morula spleen ovary dentate gyrus of hippocampal formation granule cell More reference expression data BioGPS n/a
Gene ontology Molecular function structural constituent of ribosome protein binding RNA binding mRNA 3'-UTR binding mRNA 5'-UTR binding ubiquitin ligase inhibitor activity protein kinase binding poly(U) RNA binding Cellular component cytosol ribosome membrane focal adhesion intracellular anatomical structure microtubule organizing center nucleolus extracellular exosome cytoskeleton nucleus nucleoplasm extracellular matrix cytoplasm 90S preribosome small-subunit processome centrosome cytosolic small ribosomal subunit protein-containing complex synapse ribonucleoprotein complex Biological process viral transcription SRP-dependent cotranslational protein targeting to membrane translational initiation nuclear-transcribed mRNA catabolic process, nonsense-mediated decay ribosomal small subunit biogenesis rRNA processing protein biosynthesis cytoplasmic translation positive regulation of gene expression protein stabilization positive regulation of intrinsic apoptotic signaling pathway by p53 class mediator negative regulation of ubiquitin protein ligase activity negative regulation of ubiquitin-dependent protein catabolic process neural tube closure cell differentiation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 6201 20115 Ensembl ENSG00000171863 ENSMUSG00000061477 UniProt P62081 P62082 RefSeq (mRNA) NM_001011 NM_011300 RefSeq (protein) NP_001002 NP_035430 Location (UCSC) Chr 2: 3.58 – 3.58 Mb Chr 12: 28.68 – 28.69 Mb PubMed search [3] [4]
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In eukaryotes, ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 40S subunit. The protein belongs to the S7E family of ribosomal proteins. It is located in the cytoplasm. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome.^[7]