40S ribosomal protein S8

40S ribosomal protein S8 is a protein that in humans is encoded by the RPS8 gene.^[5][6]

PDBOrtholog search: PDBe RCSB

AliasesRPS8, S8, ribosomal protein S8

External IDsOMIM: 600357; MGI: 98166; HomoloGene: 133143; GeneCards: RPS8; OMA:RPS8 - orthologs

Chr.Chromosome 1 (human)^[1]

Quick facts RPS8, Available structures ...

RPS8
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4UG0, 4V6X, 5A2Q, 5AJ0, 3J7P, 4UJE, 4D5L, 3J7R, 4UJD, 5FLX, 4D61, 4UJC
Identifiers
Aliases	RPS8, S8, ribosomal protein S8
External IDs	OMIM: 600357; MGI: 98166; HomoloGene: 133143; GeneCards: RPS8; OMA:RPS8 - orthologs
Gene location (Human) Chr. Chromosome 1 (human)[1] Band 1p34.1 Start 44,775,251 bp[1] End 44,778,779 bp[1]
Gene location (Mouse) Chr. Chromosome 4 (mouse)[2] Band 4|4 D1 Start 117,011,024 bp[2] End 117,013,440 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in left ovary right ovary canal of the cervix body of uterus fallopian tube left adrenal cortex ganglionic eminence right uterine tube right adrenal gland lymph node Top expressed in ventricular zone epiblast ganglionic eminence uterus esophagus ovary embryo ileum duodenum lens More reference expression data BioGPS n/a
Gene ontology Molecular function structural constituent of ribosome RNA binding Cellular component focal adhesion nucleus intracellular anatomical structure ribosome extracellular exosome membrane nucleoplasm cytoplasm endoplasmic reticulum cytosol cytosolic small ribosomal subunit ribonucleoprotein complex Biological process nuclear-transcribed mRNA catabolic process, nonsense-mediated decay SRP-dependent cotranslational protein targeting to membrane viral transcription maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) translational initiation protein biosynthesis rRNA processing Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 6202 20116 Ensembl ENSG00000142937 ENSMUSG00000047675 UniProt P62241 P62242 RefSeq (mRNA) NM_001012 NM_009098 RefSeq (protein) NP_001003 NP_033124 Location (UCSC) Chr 1: 44.78 – 44.78 Mb Chr 4: 117.01 – 117.01 Mb PubMed search [3] [4]
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Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 40S subunit. The protein belongs to the S8E family of ribosomal proteins. It is located in the cytoplasm. Increased expression of this gene in colorectal tumors and colon polyps compared to matched normal colonic mucosa has been observed. This gene is co-transcribed with the small nucleolar RNA genes U38A, U38B, U39, and U40, which are located in its fourth, fifth, first, and second introns, respectively. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome.^[6]