RRAGC

Ras-related GTP binding C, also known as RRAGC, is a protein which in humans is encoded by the RRAGC gene.^[5][6]

PDBOrtholog search: PDBe RCSB

AliasesRRAGC, GTR2, RAGC, TIB929, Ras related GTP binding C

External IDsOMIM: 608267; MGI: 1858751; HomoloGene: 39141; GeneCards: RRAGC; OMA:RRAGC - orthologs

Chr.Chromosome 1 (human)^[1]

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RRAGC
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3LLU
Identifiers
Aliases	RRAGC, GTR2, RAGC, TIB929, Ras related GTP binding C
External IDs	OMIM: 608267; MGI: 1858751; HomoloGene: 39141; GeneCards: RRAGC; OMA:RRAGC - orthologs
Gene location (Human) Chr. Chromosome 1 (human)[1] Band 1p34.3 Start 38,838,198 bp[1] End 38,859,772 bp[1]
Gene location (Mouse) Chr. Chromosome 4 (mouse)[2] Band 4|4 D2.2 Start 123,811,239 bp[2] End 123,830,790 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in islet of Langerhans monocyte skin of leg tibial arteries smooth muscle tissue skin of abdomen ventricular zone gastric mucosa stromal cell of endometrium right coronary artery Top expressed in secondary oocyte primary oocyte stroma of bone marrow calvaria zygote brown adipose tissue endothelial cell of lymphatic vessel motor neuron decidua white adipose tissue More reference expression data BioGPS More reference expression data
Gene ontology Molecular function nucleotide binding GTP binding protein binding GTPase activity magnesium ion binding GDP binding protein heterodimerization activity GTPase binding Cellular component cytoplasm cytosol intracellular membrane-bounded organelle lysosome nucleus Gtr1-Gtr2 GTPase complex Biological process regulation of TOR signaling small GTPase mediated signal transduction cellular response to amino acid starvation transcription, DNA-templated cell growth RNA splicing apoptotic process regulation of TORC1 signaling response to amino acid regulation of autophagy regulation of macroautophagy positive regulation of TOR signaling cellular response to amino acid stimulus cellular response to starvation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 64121 54170 Ensembl ENSG00000116954 ENSMUSG00000028646 UniProt Q9HB90 Q99K70 RefSeq (mRNA) NM_022157 NM_001271851 NM_017475 RefSeq (protein) NP_001258780 NP_071440 NP_059503 Location (UCSC) Chr 1: 38.84 – 38.86 Mb Chr 4: 123.81 – 123.83 Mb PubMed search [3] [4]
Wikidata
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RRAGC is a monomeric guanine nucleotide-binding protein, or G protein. By binding GTP or GDP, small G proteins act as molecular switches in numerous cell processes and signaling pathways.^[5]