RU-29717

RU-29717
Clinical data
Other names	RU29717; RU-29,717; N-Propyl-9-oxaergoline; 6-Propyl-9-oxaergoline; POE
Drug class	Dopamine receptor agonist; Serotonin receptor modulator
ATC code	None;
Identifiers
	IUPAC name (7R)-6-propyl-3-oxa-6,11-diazatetracyclo[7.6.1.02,7.012,16]hexadeca-1(16),9,12,14-tetraene;
CAS Number	85351-27-5;
PubChem CID	134984;
ChemSpider	118948;
Chemical and physical data
Formula	C16H20N2O
Molar mass	256.349 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES CCCN1CCOC2[C@H]1CC3=CNC4=CC=CC2=C34;
	InChI InChI=1S/C16H20N2O/c1-2-6-18-7-8-19-16-12-4-3-5-13-15(12)11(10-17-13)9-14(16)18/h3-5,10,14,16-17H,2,6-9H2,1H3/t14-,16?/m1/s1; Key:QZLSEITWUMZHSJ-IURRXHLWSA-N;

RU-29717, also known as N-propyl-9-oxaergoline or as 6-propyl-9-oxaergoline (POE), is a dopamine receptor agonist and serotonin receptor modulator of the 9-oxaergoline family closely related to ergolines such as pergolide.^[1] It produces effects including suppression of prolactin secretion, hypotension, emesis, stereotypy, and antiparkinsonian-like effects in animals.^[1]^[2] In addition to its dopamine receptor agonism, RU-29717 shows affinity for serotonin receptors (e.g., 5-HT₁ and 5-HT₂ receptors), with much higher affinity for the serotonin 5-HT₁ receptors than the related dopamine receptor agonist pergolide, though RU-29717's affinity for serotonin 5-HT₂ receptors is much lower than for serotonin 5-HT₁ receptors.^[1]^[3] Relatedly, RU-29717 also caused short-lasting head twitches in rodents, which were hypothesized to be due to serotonin receptor agonism.^[1] The head-twitch response is notable in being a behavioral proxy of psychedelic effects caused by serotonin 5-HT_2A receptor agonism.^[4]^[5] RU-29717 was described in the scientific literature in 1983 and was patented in 1985.^[1]^[6]^[2]