RUVBL2
Protein-coding gene in humans
From Wikipedia, the free encyclopedia
RuvB-like 2 (E. coli), also known as RUVBL2, is a human gene coding for a protein belonging to the AAA+ family of proteins.
AliasesRUVBL2, ECP51, INO80J, REPTIN, RVB2, TIH2, TIP48, TIP49B, CGI-46, ECP-51, TAP54-beta, RuvB like AAA ATPase 2
External IDsOMIM: 604788; MGI: 1342299; HomoloGene: 4856; GeneCards: RUVBL2; OMA:RUVBL2 - orthologs
Function
This gene encodes the second human homologue of the bacterial RuvB gene. Bacterial RuvB protein is a DNA helicase essential for homologous recombination and DNA double-strand break repair. However, the evidence for whether RUVBL2 has DNA helicase activity is contradictory.[5] This gene is physically linked to the CGB/LHB gene cluster on chromosome 19q13.3, and is very close (55 nt) to the LHB gene, in the opposite orientation.[6]
Interactions
RUVBL2 has been shown to interact with RuvB-like 1[7] and Activating transcription factor 2.[8]
