Relaxin/insulin-like family peptide receptor 2

Relaxin/insulin-like family peptide receptor 2, also known as RXFP2, is a human G-protein coupled receptor.^[5]

PDBOrtholog search: PDBe RCSB

AliasesRXFP2, GPR106, GREAT, INSL3R, LGR8, LGR8.1, RXFPR2, Relaxin/insulin-like family peptide receptor 2, relaxin/insulin like family peptide receptor 2, relaxin family peptide receptor 2

External IDsOMIM: 606655; MGI: 2153463; HomoloGene: 15402; GeneCards: RXFP2; OMA:RXFP2 - orthologs

Chr.Chromosome 13 (human)^[1]

Quick facts RXFP2, Available structures ...

RXFP2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2M96
Identifiers
Aliases	RXFP2, GPR106, GREAT, INSL3R, LGR8, LGR8.1, RXFPR2, Relaxin/insulin-like family peptide receptor 2, relaxin/insulin like family peptide receptor 2, relaxin family peptide receptor 2
External IDs	OMIM: 606655; MGI: 2153463; HomoloGene: 15402; GeneCards: RXFP2; OMA:RXFP2 - orthologs
Gene location (Human) Chr. Chromosome 13 (human)[1] Band 13q13.1 Start 31,739,526 bp[1] End 31,803,389 bp[1]
Gene location (Mouse) Chr. Chromosome 5 (mouse)[2] Band 5 G3|5 89.23 cM Start 149,942,140 bp[2] End 150,005,649 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in testicle monocyte granulocyte gonad left uterine tube blood smooth muscle tissue right adrenal cortex left adrenal gland left adrenal cortex Top expressed in mesothelium spermatocyte mesothelium of peritoneum spermatid seminiferous tubule embryo embryo vas deferens genital tubercle abdominal wall More reference expression data BioGPS n/a
Gene ontology Molecular function protein-hormone receptor activity signal transducer activity G protein-coupled receptor activity peptide hormone binding G protein-coupled peptide receptor activity Cellular component integral component of membrane membrane plasma membrane intracellular anatomical structure integral component of plasma membrane Biological process male gonad development negative regulation of apoptotic process adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway adenylate cyclase-activating G protein-coupled receptor signaling pathway oocyte maturation signal transduction negative regulation of cell population proliferation adenylate cyclase-modulating G protein-coupled receptor signaling pathway G protein-coupled receptor signaling pathway positive regulation of cAMP-mediated signaling activation of adenylate cyclase activity hormone-mediated signaling pathway Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 122042 140498 Ensembl ENSG00000133105 ENSMUSG00000053368 UniProt Q8WXD0 Q91ZZ5 RefSeq (mRNA) NM_001166058 NM_130806 NM_001289564 NM_001289566 NM_080468 RefSeq (protein) NP_001159530 NP_570718 NP_001276493 NP_001276495 NP_536716 Location (UCSC) Chr 13: 31.74 – 31.8 Mb Chr 5: 149.94 – 150.01 Mb PubMed search [3] [4]
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The receptors for glycoprotein hormones such as follicle-stimulating hormone (FSH; see MIM 136530) and thyroid-stimulating hormone (TSH; see MIM 188540) are G protein-coupled, 7-transmembrane receptors (GPCRs) with large N-terminal extracellular domains. Leucine-rich repeat (LRR)-containing GPCRs (LGRs) form a subgroup of the GPCR superfamily. [supplied by OMIM].^[5]