Rae-1 family
From Wikipedia, the free encyclopedia
Retinoic acid early inducible 1 (RAE-1) family of murine cell surface glycoproteins is composed of at least five members (RAE-1α-ε).[1] Genes encoding these proteins are located on mouse chromosome 10.[1] RAE-1 proteins are related to MHC class I, they are made up of external α1α2 domain which is linked to the cell membrane by the GPI anchor.[1] They function as stress-induced ligands for NKG2D receptor and their expression is low or absent on normal cells.[1] However, they are constitutively expressed on some tumour cells and they can be upregulated by retinoic acid.[1]
