Rebamipide

Rebamipide
Clinical data
Trade names	Mucosta (JP), Rebagen (KR, CN, IN), Rebagit (RU), Ramiper, Rebamax (ID)
AHFS/Drugs.com	International Drug Names
Routes of; administration	By mouth (tablets)
ATC code	A02BX14 (WHO) ;
Identifiers
	IUPAC name 2-[(4-chlorobenzoyl)amino]-3-(2-oxo-1H-quinolin-4-yl)propanoic acid;
CAS Number	90098-04-7 ;
PubChem CID	5042;
IUPHAR/BPS	871;
DrugBank	DB11656 ;
ChemSpider	4866 ;
UNII	LR583V32ZR;
KEGG	D01121 ;
ChEMBL	ChEMBL1697771 ;
CompTox Dashboard (EPA)	DTXSID8045937 ;
Chemical and physical data
Formula	C19H15ClN2O4
Molar mass	370.79 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES Clc1ccc(cc1)C(=O)NC(C(=O)O)CC2=CC(=O)Nc3ccccc32;
	InChI InChI=1S/C19H15ClN2O4/c20-13-7-5-11(6-8-13)18(24)22-16(19(25)26)9-12-10-17(23)21-15-4-2-1-3-14(12)15/h1-8,10,16H,9H2,(H,21,23)(H,22,24)(H,25,26) ; Key:ALLWOAVDORUJLA-UHFFFAOYSA-N ;
	(what is this?) (verify)

Rebamipide, an amino acid derivative of 2-(1H)-quinolinone, is used for mucosal protection,^[1] healing of gastroduodenal ulcers, and treatment of gastritis.^[2] It works by enhancing mucosal defense, scavenging free radicals,^[3] and temporarily activating genes encoding cyclooxygenase-2.^[4]

Trade namesMucosta (JP), Rebagen (KR, CN, IN), Rebagit (RU), Ramiper, Rebamax (ID)

AHFS/Drugs.comInternational Drug Names

Routes of
administrationBy mouth (tablets)

ATC code

A02BX14 (WHO)

Quick facts Clinical data, Trade names ...

Close

Studies have shown that rebamipide can fight the damaging effects of NSAIDs on the GIT mucosa,^[5] and more recently, the small intestine, but not for naproxen-induced gastric damage.^[6]

[1]

[2]

[3]

[4]

[5]

[6]

Rebamipide

Availability

Effects

References

Related Articles