Relmapirazin

Relmapirazin (MB-102) is an investigational fluorescent tracer that is exclusively excreted renally and is used to measure glomerular filtration rate of the kidneys.^{[1][2][3][4][5][6][7]}

Trade namesLumitrace

Other namesMB-102

ATC code

• V04CH05 (WHO)

CAS Number

• 1313706-17-0

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Relmapirazin

Clinical data
Trade names	Lumitrace
Other names	MB-102
ATC code	V04CH05 (WHO)
Identifiers
IUPAC name (2R)-2-[[3,6-Diamino-5-[[(1R)-1-carboxy-2-hydroxyethyl]carbamoyl]pyrazine-2-carbonyl]amino]-3-hydroxypropanoic acid
CAS Number	1313706-17-0
PubChem CID	53389120
UNII	Q3UQB8PQ6H
KEGG	D11637
ChEMBL	ChEMBL1949708
Chemical and physical data
Formula	C12H16N6O8
Molar mass	372.294 g·mol−1
3D model (JSmol)	Interactive image
SMILES C([C@H](C(=O)O)NC(=O)C1=C(N=C(C(=N1)N)C(=O)N[C@H](CO)C(=O)O)N)O
InChI InChI=1S/C12H16N6O8/c13-7-5(9(21)15-3(1-19)11(23)24)17-8(14)6(18-7)10(22)16-4(2-20)12(25)26/h3-4,19-20H,1-2H2,(H2,14,17)(H2,13,18)(H,15,21)(H,16,22)(H,23,24)(H,25,26)/t3-,4-/m1/s1 Key:XHNJXRDGTITISI-QWWZWVQMSA-N

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Using plasma sampling, relmapirazin has been shown to have the same properties and accuracy as iohexol for determining glomerular filtration rate in human subjects of varying kidney function.^[8] Furthermore, transdermal optical detection of the change in concentration of intravenously injected relmapirazin has been used to estimate glomerular filtration rate with excellent accuracy in human subjects of varying kidney function and skin color.^[9]