Ricobendazole

Chemical compound From Wikipedia, the free encyclopedia

Ricobendazole, also known as albendazole S-oxide, is a broad-spectrum benzimidazole anthelmintic. Its main use is for protecting livestock against nematode parasites.[1] Ricobendazole is the active sulfoxide metabolite of albendazole.[2]

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Ricobendazole
Clinical data
Trade namesRycoben
Identifiers
  • methyl [6-(propylsulfinyl)-1H-benzimidazol-2-yl]carbamate
CAS Number
PubChem CID
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ECHA InfoCard100.157.043 Edit this at Wikidata
Chemical and physical data
FormulaC12H15N3O3S
Molar mass281.33 g·mol−1
3D model (JSmol)
  • CCCS(=O)c1ccc2[nH]c(NC(=O)OC)nc2c1
  • InChI=1S/C12H15N3O3S/c1-3-6-19(17)8-4-5-9-10(7-8)14-11(13-9)15-12(16)18-2/h4-5,7H,3,6H2,1-2H3,(H2,13,14,15,16) checkY
  • Key:VXTGHWHFYNYFFV-UHFFFAOYSA-N
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Like mebendazole, ricobendazole inhibits tubulin polymerization.

Metabolic product of albendazole

Ricobendazole is produced in many species and in human liver when albendazole undergoes first-pass metabolism by the enzymes albendazole monooxygenase (sulfoxide-forming) (a cytochrome P450 oxidase) or albendazole monooxygenase (a flavin-containing monooxygenase.[3]

 
 
 
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References

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