Rifampicin/isoniazid/pyrazinamide
Combination drug
From Wikipedia, the free encyclopedia
Rifampicin/isoniazid/pyrazinamide, also known as rifampin/isoniazid/pyrazinamide, and sold under the trade name Rifater, is a medication used to treat tuberculosis.[1] It is a fixed dose combination of rifampicin, isoniazid, and pyrazinamide.[1] It is used either by itself or along with other antituberculosis medication.[1] It is taken by mouth.[1]
| Combination of | |
|---|---|
| Rifampicin | Rifamycin antibiotic |
| Isoniazid | Anti-tuberculosis medication |
| Pyrazinamide | Anti-tuberculosis medication |
| Clinical data | |
| Trade names | Rifater, Trifazid, others |
| AHFS/Drugs.com | FDA Professional Drug Information |
| License data | |
| Routes of administration | By mouth |
| ATC code | |
| Legal status | |
| Legal status |
|
| Identifiers | |
| CAS Number | |
| PubChem CID | |
| ChemSpider |
|
| KEGG | |
| (verify) | |
Side effects are those of the underlying medications.[1] These may include poor coordination, loss of appetite, nausea, joint pain, feeling tired, and numbness.[2] Severe side effects include liver problems.[3] Use in those under the age of 15 may not be appropriate.[3] It is unclear if use in pregnancy is safe for the baby.[3]
Rifampicin/isoniazid/pyrazinamide was approved for medical use in the United States in 1994.[3] It is on the World Health Organization's List of Essential Medicines.[4]
Medical uses
The hope of a fixed-dose combination pill is to increase the likelihood that people will take all of three medications.[5] Also, if people forget to take one or two of their drugs, they might not then develop resistance to the remaining drugs.[citation needed]
Society and culture
It is manufactured by Aventis.[citation needed]
