Rnd2

Protein-coding gene in the species Homo sapiens From Wikipedia, the free encyclopedia

Rnd2 is a small (~21 kDa) signaling G protein (to be specific, a GTPase), and is a member of the Rnd subgroup of the Rho family of GTPases.[5] It is encoded by the gene RND2.[6]

AliasesRND2, ARHN, RHO7, RhoN, Rnd2, Rho family GTPase 2
End43,032,041 bp[1]
Quick facts Identifiers, Aliases ...
RND2
Identifiers
AliasesRND2, ARHN, RHO7, RhoN, Rnd2, Rho family GTPase 2
External IDsOMIM: 601555; MGI: 1338755; HomoloGene: 21123; GeneCards: RND2; OMA:RND2 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_005440

NM_009708

RefSeq (protein)

NP_005431

NP_033838

Location (UCSC)Chr 17: 43.03 – 43.03 MbChr 11: 101.36 – 101.36 Mb
PubMed search[3][4]
Wikidata
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Function

It contributes to regulating the organization of the actin cytoskeleton in response to extracellular growth factors (Nobes et al., 1998).[supplied by OMIM][7]

This particular family member has been implicated in the regulation of neuronal morphology and endosomal trafficking.

Clinical significance

The gene localizes to chromosome 17 and is the centromeric neighbor of the breast-ovarian cancer susceptibility gene BRCA1.[6]

Interactions

Rnd2 has been shown to interact with:

References

Further reading

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