Difludiazepam

Difludiazepam^[1] (Ro07-4065) is a benzodiazepine derivative which is the 2',6'-difluoro derivative of fludiazepam. It was invented in the 1970s but was never marketed, and has been used as a research tool to help determine the shape and function of the GABA_A receptors, at which it has an IC₅₀ of 4.1nM.^[2][3][4] Difludiazepam has subsequently been sold as a designer drug, and was first notified to the EMCDDA by Swedish authorities in 2017.^[5][6]

Legal status

• CA: Schedule IV
• DE: NpSG (Industrial and scientific use only)
• UK: Under Psychoactive Substances Act

CAS Number

• 39080-67-6 ^Y

PubChem CID

• 44366236

ChemSpider

• 23222150

Quick facts Legal status, Identifiers ...

Difludiazepam

Legal status
Legal status	CA: Schedule IV DE: NpSG (Industrial and scientific use only) UK: Under Psychoactive Substances Act
Identifiers
IUPAC name 7-chloro-5-(2,6-difluorophenyl)-1-methyl-1H-benzo[e][1,4]diazepin-2(3H)-one
CAS Number	39080-67-6 Y
PubChem CID	44366236
ChemSpider	23222150
UNII	7N3B9XEC7B
ChEMBL	ChEMBL346673
CompTox Dashboard (EPA)	DTXSID001135292
Chemical and physical data
Formula	C16H11ClF2N2O
Molar mass	320.72 g·mol−1
3D model (JSmol)	Interactive image
SMILES Fc3cccc(F)c3C2=NCC(=O)N(C)c1ccc(Cl)cc12
InChI InChI=1S/C16H11ClF2N2O/c1-21-13-6-5-9(17)7-10(13)16(20-8-14(21)22)15-11(18)3-2-4-12(15)19/h2-7H,8H2,1H3 Key:DUNFPASORLTEGN-UHFFFAOYSA-N

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