Rociverine

Chemical compound From Wikipedia, the free encyclopedia

Rociverine is an antispasmodic drug used to treat urinary, gastrointestinal and biliary spasms.[1] It is antimuscarinic drug.[2]

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Rociverine
Clinical data
ATC code
Identifiers
  • 1-(diethylamino)propan-2-yl (1S,2S)-2-cyclohexyl-2-hydroxycyclohexane-1-carboxylate
CAS Number
PubChem CID
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UNII
KEGG
ChEBI
ChEMBL
CompTox Dashboard (EPA)
ECHA InfoCard100.053.356 Edit this at Wikidata
Chemical and physical data
FormulaC20H37NO3
Molar mass339.520 g·mol−1
3D model (JSmol)
  • CCN(CC)CC(C)OC(=O)[C@H]1CCCC[C@@]1(C2CCCCC2)O
  • InChI=InChI=1S/C20H37NO3/c1-4-21(5-2)15-16(3)24-19(22)18-13-9-10-14-20(18,23)17-11-7-6-8-12-17/h16-18,23H,4-15H2,1-3H3/t16?,18-,20+/m1/s1
  • Key:XPYLKZZOBVLVHB-QDKIRNHSSA-N
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Medical uses

In India, rociverine is used as part of the "Programmed Labour Protocol" to help reduce pain and shorten the duration of labor. However, an analysis of clinical trials provides little evidence supporting its effectiveness in reducing labor duration.[3]

Pharmacology

The (1R,2R) stereoisomer showed 240-fold greater affinity for the muscarinic receptor, but the (1S,2S) compound showed the best selectivity.[4]

References

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