Romifidine

Chemical compound From Wikipedia, the free encyclopedia

Romifidine is a drug that is used in veterinary medicine as a sedative mainly in large animals such as horses,[1] although it may be used in a wide variety of species.[2][3] It is not used in humans, but is closely related in structure to the commonly used drug clonidine.

AHFS/Drugs.comInternational Drug Names
Routes of
administrationIV
ATCvet code
Legal status
  • Veterinary use only
Quick facts Clinical data, AHFS/Drugs.com ...
Romifidine
Clinical data
AHFS/Drugs.comInternational Drug Names
Routes of
administration		IV
ATCvet code
Legal status
Legal status
  • Veterinary use only
Identifiers
  • N-(2-bromo-6-fluorophenyl)-4,5-dihydro-1H-imidazol-2-amine
CAS Number
PubChem CID
ChemSpider
UNII
CompTox Dashboard (EPA)
ECHA InfoCard100.158.065 Edit this at Wikidata
Chemical and physical data
FormulaC9H9BrFN3
Molar mass258.094 g·mol−1
3D model (JSmol)
  • C1CN=C(N1)NC2=C(C=CC=C2Br)F
  • InChI=1S/C9H9BrFN3/c10-6-2-1-3-7(11)8(6)14-9-12-4-5-13-9/h1-3H,4-5H2,(H2,12,13,14) ☒N
  • Key:KDPNLRQZHDJRFU-UHFFFAOYSA-N ☒N
 ☒NcheckY (what is this?)  (verify)
Close

Romifidine acts as an agonist at the α2 adrenergic receptor subtype. Side effects can include bradycardia and respiratory depression. It is often used alongside other sedative or analgesic drugs such as ketamine or butorphanol.[4][5] Yohimbine can be used as an antidote to rapidly reverse the effects.

Use

Romifidine is licensed for cats and dogs in several countries. Romifidine is licensed for non-meat horses. Romifidine may produce less ataxia during standing sedation than other α2-adrenergic receptor agonists.[6]

Pharmacology

Romifidine is an α2-adrenergic receptor agonist that binds at a ratio of 340:1 over the imidazoline receptor.[6]

Side effects

Romifidine administration in sheep activates pulmonary macrophages that damage the endothelium of capillaries and alveolar type I cells. This in turns causes alveolar haemorrhage and oedema causing hypoxaemia.[6][7][8]

References

Related Articles

Wikiwand AI