Rs6311
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In genetics, rs6311 is a gene variation—a single nucleotide polymorphism (SNP)—in the human HTR2A gene that codes for the 5-HT2A receptor. 5-HT2A is a neuroreceptor, and several scientific studies have investigated the effect of the genetic variation on personality, e.g., personality traits measured with the Temperament and Character Inventory[1][2][3][4] or with a psychological task measuring impulsive behavior.[5] The SNP has also been investigated in rheumatology studies.[6][7]
| SNP: rs6311 | |
|---|---|
| Name(s) | -1438G/A, -1438A/G, A-1438G, G-1438A |
| Gene | HTR2A |
| Chromosome | 13 |
| External databases | |
| Ensembl | Human SNPView |
| dbSNP | 6311 |
| HapMap | 6311 |
| SNPedia | 6311 |
| SzGene | Meta-analysis Overview |
Some research studies may refer to this gene variation as a C/T SNP,[2] while others refer to it as a G/A polymorphism in the promoter region, thus writing it as, e.g., −1438 G/A or 1438G>A.[8][9][10]
As of 2008[update], meta-analysis of research studies indicates that people with the A-allele may have slightly elevated risk of schizophrenia.[11]
rs6313, rs6314, and rs7997012 are other investigated SNPs in the HTR2A gene.
