SAP18
Protein-coding gene in the species Homo sapiens
From Wikipedia, the free encyclopedia
Histone deacetylase complex subunit SAP18 is an enzyme that in humans is encoded by the SAP18 gene.[5][6]
External IDsOMIM: 602949; MGI: 3704317; HomoloGene: 4289; GeneCards: SAP18; OMA:SAP18 - orthologs
Function
Histone acetylation plays a key role in the regulation of eukaryotic gene expression. Multisubunit complexes catalyze histone acetylation and deacetylation. The protein encoded by this gene is a histone deacetylase complex component, including SIN3, SAP30, HDAC1, HDAC2, RbAp46, RbAp48, and other polypeptides. This protein directly interacts with SIN3 and enhances SIN3-mediated transcriptional repression when tethered to the promoter.[6] Additionally, SAP18s splice variants are implicated in apoptotic cycles.[7]