SAP18

Protein-coding gene in the species Homo sapiens From Wikipedia, the free encyclopedia

Histone deacetylase complex subunit SAP18 is an enzyme that in humans is encoded by the SAP18 gene.[5][6]

PDBHuman UniProt search: PDBe RCSB
AliasesSAP18, 2HOR0202, SAP18P, Sin3A associated protein 18kDa, Sin3A associated protein 18
Quick facts Available structures, PDB ...
SAP18
Available structures
PDBHuman UniProt search: PDBe RCSB
Identifiers
AliasesSAP18, 2HOR0202, SAP18P, Sin3A associated protein 18kDa, Sin3A associated protein 18
External IDsOMIM: 602949; MGI: 3704317; HomoloGene: 4289; GeneCards: SAP18; OMA:SAP18 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_005870
NM_001366643

NM_001142441

RefSeq (protein)

NP_005861
NP_001353572

n/a

Location (UCSC)Chr 13: 21.14 – 21.15 MbChr 8: 96.55 – 96.55 Mb
PubMed search[3][4]
Wikidata
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Function

Histone acetylation plays a key role in the regulation of eukaryotic gene expression. Multisubunit complexes catalyze histone acetylation and deacetylation. The protein encoded by this gene is a histone deacetylase complex component, including SIN3, SAP30, HDAC1, HDAC2, RbAp46, RbAp48, and other polypeptides. This protein directly interacts with SIN3 and enhances SIN3-mediated transcriptional repression when tethered to the promoter.[6] Additionally, SAP18s splice variants are implicated in apoptotic cycles.[7]

Interactions

SAP18 has been shown to interact with

References

Further reading

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