SAT2

SAT2
Identifiers
Aliases	SAT2, Sspermidine/spermine N1-acetyltransferase family member 2, SSAT-2
External IDs	OMIM: 611463; MGI: 1916465; GeneCards: SAT2
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2BEI, 2Q4V
Enzyme activity
Gene location (Human)
Chr.	Chromosome 17 (human)
End	7,627,876 bp
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)
End	69,514,696 bp
RNA expression pattern
	Top expressed in
	right adrenal cortex; ; left adrenal cortex; ; jejunal mucosa; ; right lobe of liver; ; mucosa of ileum; ; duodenum; ; human kidney; ; left ovary; ; right ovary; ; anterior pituitary;
	Top expressed in
	otolith organ; ; utricle; ; retinal pigment epithelium; ; right kidney; ; proximal tubule; ; otic vesicle; ; Rostral migratory stream; ; internal carotid artery; ; external carotid artery; ; epithelium of lens;
	More reference expression data
	n/a
Gene ontology
Molecular function	transferase activity; N-acetyltransferase activity; acyltransferase activity; diamine N-acetyltransferase activity; protein binding; identical protein binding; spermidine binding;
Cellular component	cytoplasm; extracellular exosome;
Biological process	putrescine acetylation; spermine acetylation; nor-spermidine metabolic process; spermidine acetylation; putrescine catabolic process;
	Sources:Amigo / QuickGO
Orthologs
Databases	NCBI: entry; OMA: entry
	112483
	69215
	ENSG00000141504
	ENSMUSG00000069835
	Q96F10
	Q6P8J2
	NM_133491; NM_001320845; NM_001320846; NM_001320847
	NM_026991; NM_001356468; NM_001356469
	NP_001307774; NP_001307775; NP_001307776; NP_597998
	NP_081267; NP_001343397; NP_001343398
	Wikidata
View/Edit Human	View/Edit Mouse

Diamine acetyltransferase 2 is an enzyme that in humans is encoded by the SAT2 gene.^[5]^[6]^[7] SAT2 maintains a key metabolic glutamine/glutamate balance underpinning retrograde signaling by dendritic release of the neurotransmitter glutamate.^[8]