SCG5

Neuroendocrine protein 7B2 is a protein that in humans is encoded by the SCG5 gene.^[5][6][7] The protein expressed by this gene is widely distributed in neuroendocrine tissues. It functions as a chaperone protein for the proprotein convertase PC2 by blocking the aggregation of this protein, and is required for the production of an active PC2 enzyme.^[8][9] It is an intrinsically disordered protein that may also function as a chaperone for other aggregating secretory proteins in addition to proPC2 (Helwig et al. 2013). 7B2 has been identified in vertebrates and in invertebrates as low as flatworms (Protein ID: AIZ72728.1) and insects.^[10] It is also called Sgne1 and Secretogranin V. In C. elegans, it was originally called e7B2^[11] and then renamed Seven B Two (gene name sbt-1).^[12] There is a Pfam entry for this protein: Secretogranin_V (PF05281).

AliasesSCG5, 7B2, P7B2, SGNE1, SgV, secretogranin V

External IDsOMIM: 173120; MGI: 98289; HomoloGene: 37722; GeneCards: SCG5; OMA:SCG5 - orthologs

Chr.Chromosome 15 (human)^[1]

End32,697,098 bp^[1]

Quick facts Identifiers, Aliases ...

SCG5
Identifiers
Aliases	SCG5, 7B2, P7B2, SGNE1, SgV, secretogranin V
External IDs	OMIM: 173120; MGI: 98289; HomoloGene: 37722; GeneCards: SCG5; OMA:SCG5 - orthologs
Gene location (Human) Chr. Chromosome 15 (human)[1] Band 15q13.3 Start 32,641,676 bp[1] End 32,697,098 bp[1]
Gene location (Mouse) Chr. Chromosome 2 (mouse)[2] Band 2 E4|2 57.45 cM Start 113,776,362 bp[2] End 113,829,121 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in islet of Langerhans superior frontal gyrus primary visual cortex prefrontal cortex Brodmann area 9 anterior pituitary cerebellar cortex hypothalamus cerebellar hemisphere nucleus accumbens Top expressed in paraventricular nucleus of hypothalamus medial vestibular nucleus lateral geniculate nucleus medial dorsal nucleus medial geniculate nucleus dorsal tegmental nucleus pontine nuclei dorsomedial hypothalamic nucleus ventral tegmental area lateral hypothalamus More reference expression data BioGPS More reference expression data
Gene ontology Molecular function unfolded protein binding enzyme inhibitor activity GTP binding protein binding Cellular component extracellular region secretory granule Biological process regulation of hormone secretion intracellular protein transport neuropeptide signaling pathway peptide hormone processing negative regulation of catalytic activity Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 6447 20394 Ensembl ENSG00000277614 ENSG00000166922 ENSG00000281931 ENSMUSG00000023236 UniProt P05408 P12961 RefSeq (mRNA) NM_001144757 NM_003020 NM_001394278 NM_001394279 NM_009162 RefSeq (protein) NP_001138229 NP_003011 NP_033188 Location (UCSC) Chr 15: 32.64 – 32.7 Mb Chr 2: 113.78 – 113.83 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Close