Mammaglobin-A

Protein-coding gene in the species Homo sapiens From Wikipedia, the free encyclopedia

Mammaglobin-A also known as secretoglobin family 2A member 2 is a protein that in humans is encoded by the SCGB2A2 gene.[5][6][7]

AliasesSCGB2A2, MGB1, UGB2, secretoglobin family 2A member 2, PSBP1
End62,273,160 bp[1]
Quick facts SCGB2A2, Identifiers ...
SCGB2A2
Identifiers
AliasesSCGB2A2, MGB1, UGB2, secretoglobin family 2A member 2, PSBP1
External IDsOMIM: 605562; HomoloGene: 82995; GeneCards: SCGB2A2; OMA:SCGB2A2 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_002411

XM_006527538

RefSeq (protein)

NP_002402

NP_001365339

Location (UCSC)Chr 11: 62.27 – 62.27 MbChr 19: 9.85 – 9.85 Mb
PubMed search[3][4]
Wikidata
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Function

SCGB2A2 is a member of the superfamily of secretoglobins, a group of small dimeric secreted and sometimes glycosylated proteins. Expressed mainly in mucosa, secretoglobins seem to be involved in cell signalling, immune response, and chemotaxis, and may also serve as transporters for steroid hormones in humans.[8]

Clinical significance

SCGB2A2 expression is highly specific of mammary tissue, and is increasingly used for identification and detection of disseminated breast cancer cells.[9]

References

Further reading

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