SCN4B

SCN4B
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	4MZ2, 4MZ3
Identifiers
Aliases	SCN4B, ATFB17, LQT10, Navbeta4, sodium voltage-gated channel beta subunit 4
External IDs	OMIM: 608256; MGI: 2687406; HomoloGene: 18384; GeneCards: SCN4B; OMA:SCN4B - orthologs
Gene location (Human)
Chr.	Chromosome 11 (human)
End	118,152,888 bp
Gene location (Mouse)
Chr.	Chromosome 9 (mouse)
End	45,065,450 bp
RNA expression pattern
	Top expressed in
	external globus pallidus; ; spinal ganglia; ; putamen; ; right hemisphere of cerebellum; ; pons; ; caudate nucleus; ; lateral nuclear group of thalamus; ; primary visual cortex; ; Brodmann area 23; ; trigeminal ganglion;
	Top expressed in
	triceps brachii muscle; ; ankle; ; vastus lateralis muscle; ; sternocleidomastoid muscle; ; temporal muscle; ; knee joint; ; digastric muscle; ; extraocular muscle; ; medial head of gastrocnemius muscle; ; muscle of thigh;
	More reference expression data
	n/a
Gene ontology
Molecular function	sodium channel regulator activity; transmembrane transporter binding; sodium channel activity; voltage-gated ion channel activity; voltage-gated sodium channel activity involved in cardiac muscle cell action potential; voltage-gated sodium channel activity;
Cellular component	voltage-gated sodium channel complex; integral component of membrane; membrane; intercalated disc; intrinsic component of plasma membrane; plasma membrane;
Biological process	cardiac muscle contraction; sodium ion transmembrane transport; sodium ion transport; regulation of ion transmembrane transport; cardiac muscle cell action potential involved in contraction; ion transport; regulation of sodium ion transmembrane transporter activity; positive regulation of sodium ion transport; AV node cell action potential; regulation of heart rate by cardiac conduction; membrane depolarization during cardiac muscle cell action potential; regulation of ventricular cardiac muscle cell membrane repolarization;
	Sources:Amigo / QuickGO
Orthologs
	6330
	399548
	ENSG00000177098
	ENSMUSG00000046480
	Q8IWT1
	Q7M729
	NM_001142348; NM_001142349; NM_174934
	NM_001013390
	NP_001135820; NP_001135821; NP_777594
	NP_001013408
	Wikidata
View/Edit Human	View/Edit Mouse

Sodium channel β-subunit 4, also known as SCN4B or Naβ4, is an auxiliary sodium channel subunit that can alter the kinetics of sodium channels.^[5] The protein is encoded by the SCN4B gene.^[6] Mutations in the SCN4B are associated with long QT syndrome.^[7]