SEC13

Protein SEC13 homolog is a protein that in humans is encoded by the SEC13 gene.^[5][6]

PDBOrtholog search: PDBe RCSB

AliasesSEC13, D3S1231E, SEC13L1, SEC13R, npp-20, SEC13 homolog, nuclear pore and COPII coat complex component

External IDsOMIM: 600152; MGI: 99832; HomoloGene: 6479; GeneCards: SEC13; OMA:SEC13 - orthologs

Chr.Chromosome 3 (human)^[1]

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SEC13
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3BG0, 3BG1, 5A9Q
Identifiers
Aliases	SEC13, D3S1231E, SEC13L1, SEC13R, npp-20, SEC13 homolog, nuclear pore and COPII coat complex component
External IDs	OMIM: 600152; MGI: 99832; HomoloGene: 6479; GeneCards: SEC13; OMA:SEC13 - orthologs
Gene location (Human) Chr. Chromosome 3 (human)[1] Band 3p25.3 Start 10,293,131 bp[1] End 10,321,112 bp[1]
Gene location (Mouse) Chr. Chromosome 6 (mouse)[2] Band 6 E3|6 52.84 cM Start 113,705,023 bp[2] End 113,717,704 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in stromal cell of endometrium oocyte pituitary gland beta cell anterior pituitary duodenum jejunal mucosa parotid gland cartilage tissue tibia Top expressed in molar epithelium of small intestine seminal vesicula otic placode Ileal epithelium mandibular prominence maxillary prominence endocardial cushion neural tube duodenum More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding identical protein binding structural molecule activity Cellular component endoplasmic reticulum membrane intracellular membrane-bounded organelle membrane nuclear envelope nuclear pore nucleoplasm GATOR2 complex nuclear pore outer ring endoplasmic reticulum ER to Golgi transport vesicle membrane extracellular exosome cytoplasmic vesicle nucleus kinetochore Golgi membrane lysosome lysosomal membrane COPII vesicle coat cytosol host cell Biological process mRNA transport antigen processing and presentation of exogenous peptide antigen via MHC class II antigen processing and presentation of peptide antigen via MHC class I COPII vesicle coating protein transport intracellular protein transport vesicle-mediated transport positive regulation of TOR signaling sister chromatid cohesion COPII-coated vesicle cargo loading transport protein exit from endoplasmic reticulum COPII-coated vesicle budding positive regulation of TORC1 signaling regulation of glycolytic process mRNA export from nucleus tRNA export from nucleus viral process viral transcription regulation of gene silencing by miRNA intracellular transport of virus regulation of cellular response to heat Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 6396 110379 Ensembl ENSG00000157020 ENSMUSG00000030298 UniProt P55735 Q9D1M0 RefSeq (mRNA) NM_001136026 NM_001136232 NM_001278946 NM_030673 NM_183352 NM_024206 RefSeq (protein) NP_001129498 NP_001129704 NP_001265875 NP_109598 NP_899195 NP_077168 Location (UCSC) Chr 3: 10.29 – 10.32 Mb Chr 6: 113.71 – 113.72 Mb PubMed search [3] [4]
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The protein encoded by this gene belongs to the SEC13 family of WD-repeat proteins. It has similarity to the yeast SEC13 and SEC31 proteins, which are required for vesicle biogenesis from the endoplasmic reticulum during the transport of proteins.^[6]