SEC22B
Protein-coding gene in the species Homo sapiens
From Wikipedia, the free encyclopedia
Vesicle-trafficking protein SEC22b is a protein that in humans is encoded by the SEC22B gene.[5][6][7]
Function
The protein encoded by this gene is a member of the SEC22 family of vesicle trafficking proteins. It associates with other SNARE proteins to form a SNARE complex and it is thought to play a role in the ER-Golgi protein trafficking. It is required for platelet alpha-granule biogenesis in megakaryocytes[8] and is essential for the elongated morphology of endothelial cell Weibel-Palade bodies.[9] This protein has strong similarity to Mus musculus and Cricetulus griseus proteins. There is evidence for use of multiple polyadenylation sites for the transcript.[7] SEC22B has been shown to interact with syntaxin 18[10] and syntaxin 5.[11]
