SEL1L

SEL1L
Identifiers
Aliases	SEL1L, PRO1063, SEL1-LIKE, SEL1L1, SEL1L ERAD E3 ligase adaptor subunit, ERAD E3 ligase adaptor subunit, Hrd3, SEL1L adaptor subunit of ERAD E3 ubiquitin ligase
External IDs	OMIM: 602329; MGI: 1329016; HomoloGene: 31286; GeneCards: SEL1L; OMA:SEL1L - orthologs
Gene location (Human)
Chr.	Chromosome 14 (human)
End	81,533,853 bp
Gene location (Mouse)
Chr.	Chromosome 12 (mouse)
End	91,815,931 bp
RNA expression pattern
	Top expressed in
	body of pancreas; ; epithelium of colon; ; bone marrow cell; ; pericardium; ; decidua; ; cardia; ; pylorus; ; islet of Langerhans; ; jejunal mucosa; ; mucosa of ileum;
	Top expressed in
	submandibular gland; ; lacrimal gland; ; parotid gland; ; cumulus cell; ; Paneth cell; ; vestibular membrane of cochlear duct; ; pancreas; ; internal carotid artery; ; Rostral migratory stream; ; epithelium of stomach;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	protein binding;
Cellular component	integral component of membrane; Hrd1p ubiquitin ligase complex; endoplasmic reticulum membrane; Derlin-1 retrotranslocation complex; membrane; endoplasmic reticulum; endoplasmic reticulum quality control compartment; Hrd1p ubiquitin ligase ERAD-L complex;
Biological process	Notch signaling pathway; protein stabilization; retrograde protein transport, ER to cytosol; ubiquitin-dependent ERAD pathway; response to endoplasmic reticulum stress; endoplasmic reticulum mannose trimming; triglyceride metabolic process; protein secretion; ERAD pathway; transmembrane transport;
	Sources:Amigo / QuickGO
Orthologs
	6400
	20338
	ENSG00000071537
	ENSMUSG00000020964
	Q9UBV2
	Q9Z2G6
	NM_001244984; NM_005065
	NM_001039089; NM_011344
	NP_001231913; NP_005056
	NP_001034178; NP_035474
	Wikidata
View/Edit Human	View/Edit Mouse

Protein sel-1 homolog 1 is a protein that in humans is encoded by the SEL1L gene.^[5]^[6]^[7]^[8]

AliasesSEL1L, PRO1063, SEL1-LIKE, SEL1L1, SEL1L ERAD E3 ligase adaptor subunit, ERAD E3 ligase adaptor subunit, Hrd3, SEL1L adaptor subunit of ERAD E3 ubiquitin ligase

External IDsOMIM: 602329; MGI: 1329016; HomoloGene: 31286; GeneCards: SEL1L; OMA:SEL1L - orthologs

Chr.Chromosome 14 (human)^[1]

End81,533,853 bp^[1]

Quick facts Identifiers, Aliases ...

Close

[5]

[6]

[7]

[8]

[1]

[2]

[3]

[4]

SEL1L

Clinical relevance

References

Further reading

Related Articles

Related Articles

"A SEL1L Mutation Links a Canine Progressive Early-Onset Cerebellar Ataxia to the Endoplasmic Reticulum–Associated Protein Degradation (ERAD) Machinery"

"The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment"

"Multiprotein complexes that link dislocation, ubiquitination, and extraction of misfolded proteins from the endoplasmic reticulum membrane"

"SEL1L affects human pancreatic cancer cell cycle and invasiveness through modulation of PTEN and genes related to cell-matrix interactions"