SEMA3F

Semaphorin-3F is a protein that in humans is encoded by the SEMA3F gene.^[5][6][7]

AliasesSEMA3F, SEMA-IV, SEMA4, SEMAK, semaphorin 3F

External IDsOMIM: 601124; MGI: 1096347; HomoloGene: 20885; GeneCards: SEMA3F; OMA:SEMA3F - orthologs

Chr.Chromosome 3 (human)^[1]

End50,189,075 bp^[1]

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SEMA3F
Identifiers
Aliases	SEMA3F, SEMA-IV, SEMA4, SEMAK, semaphorin 3F
External IDs	OMIM: 601124; MGI: 1096347; HomoloGene: 20885; GeneCards: SEMA3F; OMA:SEMA3F - orthologs
Gene location (Human) Chr. Chromosome 3 (human)[1] Band 3p21.31 Start 50,155,045 bp[1] End 50,189,075 bp[1]
Gene location (Mouse) Chr. Chromosome 9 (mouse)[2] Band 9|9 F1 Start 107,558,699 bp[2] End 107,587,674 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in gingival epithelium pancreatic ductal cell skin of hip mucosa of pharynx human penis skin of thigh hair follicle beta cell skin of abdomen nasal epithelium Top expressed in neural layer of retina lip esophagus genital tubercle right lung ventricular zone corneal stroma left lung epithelium of bronchus lens More reference expression data BioGPS More reference expression data
Gene ontology Molecular function chemorepellent activity neuropilin binding semaphorin receptor binding Cellular component extracellular region extracellular space glutamatergic synapse integral component of plasma membrane Biological process sympathetic ganglion development ventral trunk neural crest cell migration semaphorin-plexin signaling pathway involved in neuron projection guidance negative chemotaxis semaphorin-plexin signaling pathway involved in axon guidance axon guidance sympathetic neuron projection guidance neural crest cell migration involved in autonomic nervous system development branchiomotor neuron axon guidance facial nerve structural organization nerve development sympathetic neuron projection extension trigeminal nerve structural organization axon extension involved in axon guidance neural crest cell migration negative regulation of axon extension involved in axon guidance regulation of postsynapse organization positive regulation of cell migration semaphorin-plexin signaling pathway Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 6405 20350 Ensembl ENSG00000001617 ENSMUSG00000034684 UniProt Q13275 O88632 RefSeq (mRNA) NM_004186 NM_001318798 NM_001318800 NM_011349 NM_001311151 NM_001379496 RefSeq (protein) NP_001305727 NP_001305729 NP_004177 NP_001298080 NP_035479 NP_001366425 NP_001391952 NP_001391953 NP_001391954 Location (UCSC) Chr 3: 50.16 – 50.19 Mb Chr 9: 107.56 – 107.59 Mb PubMed search [3] [4]
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The semaphorins are a family of proteins that are involved in signaling. All the family members have a secretion signal, a 500-amino acid sema domain, and 16 conserved cysteine residues (Kolodkin et al., 1993). Sequence comparisons have grouped the secreted semaphorins into 3 general classes (classes 2, 3 and V), all of which also have an immunoglobulin domain. The semaphorin 3 family, consisting of human semaphorins 3A-G (SEMA3A; MIM 603961), chicken collapsin, and mouse semaphorins 3A-G, all have a basic domain at the C terminus. Chicken collapsin contributes to path finding by axons during development by inhibiting extension of growth cones (Luo et al., 1993) through an interaction with a collapsin response mediator protein of relative molecular mass 62K (CRMP62) (Goshima et al., 1995), a putative homolog of an axonal guidance associated UNC33 gene product (MIM 601168). SEMA3F is a secreted member of the semaphorin III family.[supplied by OMIM]^[7]