SEMA6C

Semaphorin-6C is a protein that in humans is encoded by the SEMA6C gene.^[5][6]

AliasesSEMA6C, SEMAY, m-SemaY, m-SemaY2, semaphorin 6C, Sema-Y

External IDsOMIM: 609294; MGI: 1338032; HomoloGene: 7931; GeneCards: SEMA6C; OMA:SEMA6C - orthologs

Chr.Chromosome 1 (human)^[1]

End151,146,631 bp^[1]

Quick facts Identifiers, Aliases ...

SEMA6C
Identifiers
Aliases	SEMA6C, SEMAY, m-SemaY, m-SemaY2, semaphorin 6C, Sema-Y
External IDs	OMIM: 609294; MGI: 1338032; HomoloGene: 7931; GeneCards: SEMA6C; OMA:SEMA6C - orthologs
Gene location (Human) Chr. Chromosome 1 (human)[1] Band 1q21.3 Start 151,131,685 bp[1] End 151,146,631 bp[1]
Gene location (Mouse) Chr. Chromosome 3 (mouse)[2] Band 3|3 F2.1 Start 95,160,457 bp[2] End 95,174,024 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in muscle of thigh apex of heart gastrocnemius muscle right hemisphere of cerebellum right testis ganglionic eminence left testis Skeletal muscle tissue of rectus abdominis triceps brachii muscle left ventricle Top expressed in muscle of thigh triceps brachii muscle temporal muscle sternocleidomastoid muscle spermatocyte vastus lateralis muscle intercostal muscle pyloric antrum tibialis anterior muscle ankle More reference expression data BioGPS More reference expression data
Gene ontology Molecular function semaphorin receptor binding chemorepellent activity neuropilin binding Cellular component integral component of membrane plasma membrane membrane integral component of plasma membrane cytoplasm cell surface extracellular space Biological process multicellular organism development cell differentiation nervous system development axon guidance negative regulation of axon extension neural crest cell migration positive regulation of cell migration negative regulation of axon extension involved in axon guidance negative chemotaxis semaphorin-plexin signaling pathway Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 10500 20360 Ensembl ENSG00000143434 ENSMUSG00000038777 UniProt Q9H3T2 Q9WTM3 RefSeq (mRNA) NM_001178061 NM_001178062 NM_030913 NM_001272024 NM_011351 RefSeq (protein) NP_001171532 NP_001171533 NP_112175 NP_001258953 NP_035481 Location (UCSC) Chr 1: 151.13 – 151.15 Mb Chr 3: 95.16 – 95.17 Mb PubMed search [3] [4]
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This gene product is a member of the semaphorin family of proteins. Semaphorins represent important molecular signals controlling multiple aspects of the cellular response that follows CNS injury, and thus may play an important role in neural regeneration.^[6]