SEMG2

Semenogelin-2 is a protein that in humans is encoded by the SEMG2 gene.^[3][4][5]

AliasesSEMG2, SGII, semenogelin II, semenogelin 2

External IDsOMIM: 182141; HomoloGene: 129832; GeneCards: SEMG2; OMA:SEMG2 - orthologs

Chr.Chromosome 20 (human)^[1]

End45,224,458 bp^[1]

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SEMG2
Identifiers
Aliases	SEMG2, SGII, semenogelin II, semenogelin 2
External IDs	OMIM: 182141; HomoloGene: 129832; GeneCards: SEMG2; OMA:SEMG2 - orthologs
Gene location (Human) Chr. Chromosome 20 (human)[1] Band 20q13.12 Start 45,221,373 bp[1] End 45,224,458 bp[1]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in seminal vesicula sperm testicle olfactory zone of nasal mucosa epithelium of colon prostate metanephros human kidney human musculoskeletal system muscular system n/a More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protease binding protein binding metal ion binding zinc ion binding Cellular component extracellular region extracellular exosome nucleus extracellular space Biological process antibacterial humoral response positive regulation of serine-type endopeptidase activity protein heterooligomerization negative regulation of flagellated sperm motility coagulation sperm capacitation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 6407 n/a Ensembl ENSG00000124157 n/a UniProt Q02383 n/a RefSeq (mRNA) NM_003008 n/a RefSeq (protein) NP_002999 n/a Location (UCSC) Chr 20: 45.22 – 45.22 Mb n/a PubMed search [2] n/a
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The secreted protein encoded by this gene is involved in the formation of a gel matrix that encases ejaculated spermatozoa. Proteolysis by the prostate-specific antigen (PSA) breaks down the gel matrix and allows the spermatozoa to move more freely. The encoded protein is found in lesser abundance than a similar semenogelin protein. The genes encoding these two semenogelin proteins are found in a cluster on chromosome 20.^[5]