SEPP1

Selenoprotein P is a protein that in humans is encoded by the SEPP1 gene.^[5][6]

AliasesSELENOP, SELP, SeP, SEPP, SEPP1, selenoprotein P, plasma, 1, selenoprotein P

External IDsOMIM: 601484; MGI: 894288; HomoloGene: 3945; GeneCards: SELENOP; OMA:SELENOP - orthologs

Chr.Chromosome 5 (human)^[1]

End42,887,392 bp^[1]

Quick facts SELENOP, Identifiers ...

SELENOP
Identifiers
Aliases	SELENOP, SELP, SeP, SEPP, SEPP1, selenoprotein P, plasma, 1, selenoprotein P
External IDs	OMIM: 601484; MGI: 894288; HomoloGene: 3945; GeneCards: SELENOP; OMA:SELENOP - orthologs
Gene location (Human) Chr. Chromosome 5 (human)[1] Band 5p12 Start 42,799,880 bp[1] End 42,887,392 bp[1]
Gene location (Mouse) Chr. Chromosome 15 (mouse)[2] Band 15 A1|15 1.84 cM Start 3,298,029 bp[2] End 3,309,990 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in jejunal mucosa germinal epithelium superficial temporal artery parietal pleura caput epididymis inferior ganglion of vagus nerve visceral pleura corpus epididymis pars reticulata lactiferous duct Top expressed in stroma of bone marrow intestinal villus sciatic nerve iris jejunum left lobe of liver mesenteric lymph nodes right kidney ileum calvaria More reference expression data BioGPS n/a
Gene ontology Molecular function selenium binding Cellular component extracellular exosome platelet dense granule lumen extracellular region extracellular space Biological process brain development post-embryonic development sexual reproduction response to oxidative stress locomotory behavior selenium compound metabolic process platelet degranulation growth response to selenium ion regulation of growth Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 6414 20363 Ensembl ENSG00000250722 ENSMUSG00000064373 UniProt P49908 P70274 RefSeq (mRNA) NM_005410 NM_001085486 NM_001093726 NM_001042613 NM_001042614 NM_009155 RefSeq (protein) NP_001078955 NP_001087195 NP_005401 NP_001036078 NP_001036079 NP_033181 Location (UCSC) Chr 5: 42.8 – 42.89 Mb Chr 15: 3.3 – 3.31 Mb PubMed search [3] [4]
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This gene encodes a selenoprotein containing multiple selenocysteine (Sec) residues, which are encoded by the UGA codon that normally signals translation termination. The 3' UTR of selenoprotein genes have a common stem-loop structure, the sec insertion sequence (SECIS), which is necessary for the recognition of UGA as a Sec codon rather than as a stop signal. This selenoprotein is an extracellular glycoprotein, and is unusual in that it contains 10 Sec residues (human, rat, mouse)^[7] per polypeptide, one located at the C-terminal side of protein and others at the N-terminal side. It is a heparin-binding protein that appears to be associated with endothelial cells, and has been implicated to function as an antioxidant in the extracellular space. Several transcript variants, encoding either the same or different isoform, have been found for this gene.^[6] Similar proteins are widespread in eukaryotes; see Selenoprotein P.