SEPT2
Protein-coding gene in the species Homo sapiens
From Wikipedia, the free encyclopedia
Septin 2, also known as SEPT2, is a protein which in humans is encoded by the SEPT2 gene.[4][5]
External IDsOMIM: 601506; MGI: 97298; HomoloGene: 3243; GeneCards: SEPTIN2; OMA:SEPTIN2 - orthologs
Function
SEPT2 can hetero-oligomerize with SEPT6 and SEPT7 to form filaments.[6] SEPT2 interacted with SEPT6 through its C-terminal coiled-coil domain.[6] Knockdown of SEPT2, SEPT6, and SEPT7 in causes actin stress fibers to disintegrate and cells to lose polarity. Septins, SOCS7, and NCK1 are part of a signaling pathway that ties regulation of the DNA damage response to the cytoskeleton.[7]
