Kallistatin

Kallistatin is a protein that in humans is encoded by the SERPINA4 gene.^[3][4]

AliasesSERPINA4, KAL, KLST, KST, PI-4, PI4, kallistatin, serpin family A member 4

External IDsOMIM: 147935; HomoloGene: 48412; GeneCards: SERPINA4; OMA:SERPINA4 - orthologs

Chr.Chromosome 14 (human)^[1]

End94,569,913 bp^[1]

Quick facts SERPINA4, Identifiers ...

SERPINA4
Identifiers
Aliases	SERPINA4, KAL, KLST, KST, PI-4, PI4, kallistatin, serpin family A member 4
External IDs	OMIM: 147935; HomoloGene: 48412; GeneCards: SERPINA4; OMA:SERPINA4 - orthologs
Gene location (Human) Chr. Chromosome 14 (human)[1] Band 14q32.13 Start 94,561,442 bp[1] End 94,569,913 bp[1]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right lobe of liver body of pancreas gallbladder islet of Langerhans corpus epididymis caput epididymis body of stomach seminal vesicula tail of epididymis tibialis anterior muscle n/a More reference expression data BioGPS More reference expression data
Gene ontology Molecular function peptidase inhibitor activity serine-type endopeptidase inhibitor activity Cellular component extracellular exosome platelet dense granule lumen extracellular space extracellular region Biological process negative regulation of peptidase activity platelet degranulation negative regulation of endopeptidase activity Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 5267 n/a Ensembl ENSG00000100665 n/a UniProt P29622 n/a RefSeq (mRNA) NM_006215 NM_001289032 NM_001289033 n/a RefSeq (protein) NP_001275961 NP_001275962 NP_006206 n/a Location (UCSC) Chr 14: 94.56 – 94.57 Mb n/a PubMed search [2] n/a
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Kallistatin consists of three folded ß segments and eight helical structures and contains two functional domains, an active site and a heparin-binding site.

Kallistatin signals through several receptors, including integrin ß3, lipoprotein receptor-related protein 6 (LRP6), nucleolin, and Krüppel-like factor 4 (KLF4).^[5][6]