SERPINB9

Serpin B9 is a protein that in humans is encoded by the SERPINB9 gene.^[5][6][7] Serpin B9 is an inhibitor of Granzyme B (GzmB). GzmB is a potent cytotoxic molecule that is secreted by cytotoxic T lymphocytes and natural killer (NK) cells to induce apoptosis in target cells during an immune response. Serpin B9, expressed in the cytosol and nucleus, thus protects from apoptosis by cytotoxic T lymphocytes and NK cells.^[8]

AliasesSERPINB9, CAP-3, CAP3, PI-9, PI9, serpin family B member 9

External IDsOMIM: 601799; MGI: 106603; HomoloGene: 37888; GeneCards: SERPINB9; OMA:SERPINB9 - orthologs

Chr.Chromosome 6 (human)^[1]

End2,903,309 bp^[1]

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SERPINB9
Identifiers
Aliases	SERPINB9, CAP-3, CAP3, PI-9, PI9, serpin family B member 9
External IDs	OMIM: 601799; MGI: 106603; HomoloGene: 37888; GeneCards: SERPINB9; OMA:SERPINB9 - orthologs
Gene location (Human) Chr. Chromosome 6 (human)[1] Band 6p25.2 Start 2,887,270 bp[1] End 2,903,309 bp[1]
Gene location (Mouse) Chr. Chromosome 13 (mouse)[2] Band 13 A3.2- A3.3|13 13.79 cM Start 33,187,233 bp[2] End 33,201,940 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in epithelium of nasopharynx mononuclear cell monocyte germinal epithelium appendix lymph node placenta tibial nerve blood granulocyte Top expressed in right lung lobe gastrula left lung mesenteric lymph nodes left lung lobe placenta lumbar spinal ganglion Epithelium of choroid plexus carotid body spleen More reference expression data BioGPS More reference expression data
Gene ontology Molecular function peptidase inhibitor activity cysteine-type endopeptidase inhibitor activity involved in apoptotic process protease binding protein binding serine-type endopeptidase inhibitor activity Cellular component cytosol membrane intracellular anatomical structure extracellular exosome nucleus cytoplasm extracellular space nucleoplasm Golgi apparatus collagen-containing extracellular matrix Biological process negative regulation of peptidase activity mast cell mediated immunity negative regulation of apoptotic process protection from natural killer cell mediated cytotoxicity cellular response to estrogen stimulus positive regulation of gene expression negative regulation by symbiont of host apoptotic process immune response negative regulation of endopeptidase activity apoptotic process negative regulation of cysteine-type endopeptidase activity involved in apoptotic process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 5272 20723 Ensembl ENSG00000170542 ENSMUSG00000045827 UniProt P50453 O08797 RefSeq (mRNA) NM_004155 NM_009256 RefSeq (protein) NP_004146 NP_004146.1 NP_033282 Location (UCSC) Chr 6: 2.89 – 2.9 Mb Chr 13: 33.19 – 33.2 Mb PubMed search [3] [4]
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Serpin B9 belongs to the large superfamily of serine proteinase inhibitors (serpins), which bind to and inactivate serine proteinases. These interactions are involved in many cellular processes, including coagulation, fibrinolysis, complement fixation, matrix remodeling, and apoptosis (Sprecher et al., 1995).[supplied by OMIM]^[7]