SESN1

SESN1
Identifiers
Aliases	SESN1, PA26, SEST1, sestrin 1
External IDs	OMIM: 606103; MGI: 2155278; HomoloGene: 8697; GeneCards: SESN1; OMA:SESN1 - orthologs
Gene location (Human)
Chr.	Chromosome 6 (human)
End	109,094,846 bp
Gene location (Mouse)
Chr.	Chromosome 10 (mouse)
End	41,784,420 bp
RNA expression pattern
	Top expressed in
	Skeletal muscle tissue of rectus abdominis; ; muscle of thigh; ; thoracic diaphragm; ; glutes; ; gastrocnemius muscle; ; muscle of arm; ; biceps brachii; ; Skeletal muscle tissue of biceps brachii; ; triceps brachii muscle; ; right ovary;
	Top expressed in
	myocardium of ventricle; ; intercostal muscle; ; conjunctival fornix; ; ciliary body; ; cerebellar vermis; ; interventricular septum; ; iris; ; lobe of cerebellum; ; retinal pigment epithelium; ; vestibular membrane of cochlear duct;
	More reference expression data
	n/a
Gene ontology
Molecular function	oxidoreductase activity; peroxiredoxin activity; protein binding; leucine binding; oxidoreductase activity, acting on peroxide as acceptor;
Cellular component	cytosol; cytoplasm; GATOR2 complex; nucleus; fibrillar center; TORC2 complex;
Biological process	regulation of response to reactive oxygen species; reactive oxygen species metabolic process; cellular oxidant detoxification; negative regulation of TORC1 signaling; cellular response to amino acid starvation; cellular response to glucose starvation; positive regulation of macroautophagy; cellular response to amino acid stimulus; cellular response to leucine; cellular response to leucine starvation;
	Sources:Amigo / QuickGO
Orthologs
	27244
	140742
	ENSG00000080546
	ENSMUSG00000038332
	Q9Y6P5
	P58006
	NM_014454; NM_001199933; NM_001199934
	NM_001013370; NM_001162908
	NP_001186862; NP_001186863; NP_055269
	NP_001013388; NP_001156380
	Wikidata
View/Edit Human	View/Edit Mouse

Sestrin 1, also known as p53-regulated protein PA26, is a protein that in humans is encoded by the SESN1 gene. This gene encodes a member of the sestrin family. Sestrins are induced by the p53 tumor suppressor protein and play a role in the cellular response to DNA damage and oxidative stress. The encoded protein mediates p53 inhibition of cell growth by activating AMP-activated protein kinase, which results in the inhibition of the mammalian target of rapamycin protein. The encoded protein also plays a critical role in antioxidant defense by regenerating overoxidized peroxiredoxins, and the expression of this gene is a potential marker for exposure to radiation. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.^[5]^[6]^[7]