SFRP5

Secreted frizzled-related protein 5 is a protein that in humans is encoded by the SFRP5 gene.^[5][6]

AliasesSFRP5, SARP3, secreted frizzled related protein 5

External IDsOMIM: 604158; MGI: 1860298; HomoloGene: 2268; GeneCards: SFRP5; OMA:SFRP5 - orthologs

Chr.Chromosome 10 (human)^[1]

End97,771,999 bp^[1]

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SFRP5
Identifiers
Aliases	SFRP5, SARP3, secreted frizzled related protein 5
External IDs	OMIM: 604158; MGI: 1860298; HomoloGene: 2268; GeneCards: SFRP5; OMA:SFRP5 - orthologs
Gene location (Human) Chr. Chromosome 10 (human)[1] Band 10q24.2 Start 97,766,751 bp[1] End 97,771,999 bp[1]
Gene location (Mouse) Chr. Chromosome 19 (mouse)[2] Band 19|19 C3 Start 42,186,410 bp[2] End 42,190,691 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in retinal pigment epithelium tibial nerve body of pancreas sural nerve right auricle of heart cardiac muscle tissue of right atrium muscle layer of sigmoid colon olfactory bulb cartilage tissue duodenum Top expressed in sciatic nerve decidua gastrula vestibular sensory epithelium lumbar spinal ganglion lacrimal gland islet of Langerhans parotid gland retinal pigment epithelium white adipose tissue More reference expression data BioGPS More reference expression data
Gene ontology Molecular function G protein-coupled receptor activity Wnt-protein binding Wnt-activated receptor activity Cellular component extracellular region extracellular space integral component of membrane Biological process cell differentiation negative regulation of protein kinase B signaling negative regulation of Wnt signaling pathway anatomical structure morphogenesis Wnt signaling pathway negative regulation of DNA-binding transcription factor activity multicellular organism development establishment or maintenance of cell polarity negative regulation of Wnt signaling pathway involved in digestive tract morphogenesis negative regulation of canonical Wnt signaling pathway signal transduction visual perception negative regulation of cell population proliferation apoptotic process regulation of Wnt signaling pathway regulation of BMP signaling pathway G protein-coupled receptor signaling pathway non-canonical Wnt signaling pathway canonical Wnt signaling pathway Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 6425 54612 Ensembl ENSG00000120057 ENSMUSG00000018822 UniProt Q5T4F7 Q9WU66 RefSeq (mRNA) NM_003015 NM_018780 RefSeq (protein) NP_003006 NP_061250 Location (UCSC) Chr 10: 97.77 – 97.77 Mb Chr 19: 42.19 – 42.19 Mb PubMed search [3] [4]
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Secreted frizzled-related protein 5 (SFRP5) is a member of the SFRP family that contains a cysteine-rich domain homologous to the putative Wnt-binding site of Frizzled proteins. SFRPs act as soluble modulators of Wnt signaling. SFRP5 and SFRP1 may be involved in determining the polarity of photoreceptor cells in the retina. SFRP5 is highly expressed in the retinal pigment epithelium, and moderately expressed in the pancreas.^[6]