SGK2

Serine/threonine-protein kinase Sgk2 is an enzyme that in humans is encoded by the SGK2 gene.^[5][6]

AliasesSGK2, H-dJ138B7.2, serine/threonine kinase 2, serum/glucocorticoid regulated kinase 2

External IDsOMIM: 607589; MGI: 1351318; HomoloGene: 8446; GeneCards: SGK2; OMA:SGK2 - orthologs

Chr.Chromosome 20 (human)^[1]

End43,588,237 bp^[1]

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SGK2
Identifiers
Aliases	SGK2, H-dJ138B7.2, serine/threonine kinase 2, serum/glucocorticoid regulated kinase 2
External IDs	OMIM: 607589; MGI: 1351318; HomoloGene: 8446; GeneCards: SGK2; OMA:SGK2 - orthologs
Gene location (Human) Chr. Chromosome 20 (human)[1] Band 20q13.12 Start 43,558,968 bp[1] End 43,588,237 bp[1]
Gene location (Mouse) Chr. Chromosome 2 (mouse)[2] Band 2|2 H2 Start 162,829,250 bp[2] End 162,856,047 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in mucosa of transverse colon right lobe of liver rectum human kidney C1 segment renal medulla duodenum body of pancreas kidney tubule mucosa of ileum Top expressed in right kidney human kidney left lobe of liver proximal tubule pyloric antrum mucous cell of stomach epithelium of stomach large intestine ileum intestinal villus More reference expression data BioGPS More reference expression data
Gene ontology Molecular function ATP binding calcium channel regulator activity sodium channel regulator activity protein kinase activity potassium channel regulator activity kinase activity chloride channel regulator activity nucleotide binding transferase activity protein serine/threonine kinase activity Cellular component nucleus intracellular anatomical structure cytosol cytoplasm nucleoplasm cellular component Biological process response to oxidative stress positive regulation of transporter activity regulation of cell population proliferation ion transmembrane transport protein phosphorylation intracellular signal transduction peptidyl-serine phosphorylation regulation of apoptotic process phosphorylation regulation of cell growth Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 10110 27219 Ensembl ENSG00000101049 ENSMUSG00000017868 UniProt Q9HBY8 Q5H8Y5 Q9QZS5 RefSeq (mRNA) NM_170693 NM_001199264 NM_016276 NM_001291152 NM_001291154 NM_013731 RefSeq (protein) NP_001186193 NP_057360 NP_733794 NP_001278081 NP_001278083 NP_038759 Location (UCSC) Chr 20: 43.56 – 43.59 Mb Chr 2: 162.83 – 162.86 Mb PubMed search [3] [4]
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This gene encodes a serine/threonine protein kinase. Although this gene product is similar to serum- and glucocorticoid-induced protein kinase (SGK), this gene is not induced by serum or glucocorticoids. This gene is induced in response to signals that activate phosphatidylinositol 3-kinase (PI3K), which is also true for SGK. Two alternate transcripts encoding two different isoforms have been described.^[6]