SGK3

Protein-coding gene in the species Homo sapiens From Wikipedia, the free encyclopedia

Serine/threonine-protein kinase Sgk3 is an enzyme that in humans is encoded by the SGK3 gene.[5][6][7]

AliasesSGK3, CISK, SGK2, SGKL, serum/glucocorticoid regulated kinase family member 3
End66,862,022 bp[1]
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SGK3
Identifiers
AliasesSGK3, CISK, SGK2, SGKL, serum/glucocorticoid regulated kinase family member 3
External IDsOMIM: 607591; MGI: 2182368; HomoloGene: 56582; GeneCards: SGK3; OMA:SGK3 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_170709
NM_001033578
NM_013257

NM_001037759
NM_133220
NM_177547

RefSeq (protein)

NP_001191102
NP_001028750
NP_037389
NP_733827

NP_001032848
NP_573483
NP_808215

Location (UCSC)Chr 8: 66.71 – 66.86 MbChr 1: 9.87 – 9.97 Mb
PubMed search[3][4]
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Function

This gene is a member of the serine/threonine protein kinase family and encodes a phosphoprotein with a PX (phox homology) domain. The protein phosphorylates several target proteins and has a role in neutral amino acid transport and activation of potassium and chloride channels. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.[7]

In melanocytic cells SGK3 gene expression may be regulated by MITF.[8]

Interactions

SGK3 has been shown to interact with GSK3B.[9]

References

Further reading

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