SGTA
From Wikipedia, the free encyclopedia
Small glutamine-rich tetratricopeptide repeat-containing protein alpha is a protein that in humans is encoded by the SGTA gene.[1][2][3] SGTA orthologs[4] have also been identified in several mammals for which complete genome data are available. STGA belongs to a family of co-chaperone proteins that obtain a TPR motif.[5] STGA was discovered just 15 years ago.
Function
The molecular function of the protein states that SGTA is a small glutamine-rich tetratricopeptide repeat (TRP)-containing protein, ubiquitously expressed, interacting with the NS1 protein of parvovirus H-1.[10]
The SGTA gene encodes a protein that is capable of interacting with the major nonstructural protein of parvovirus H-1 and 70-kDa heat shock cognate protein; however, its function is not known. Since this transcript is expressed ubiquitously in various tissues, this protein may serve a housekeeping function.[3]
Overview of main functions:[5]
- hormone signaling
- viral assembly and release
- cell cycle and apoptosis
- intracellular compartmentalization
- neuronal synaptic transmission
- post-translational transport and modification of proteins.
Small glutamine-rich tetratricopeptide repeat-containing protein alpha (STGA) acts as a co-chaperone and regulator of androgen and growth hormone receptor signaling.[5] The protein also mediates targets to the endoplasmic reticulum
Interactions
Associated Diseases
Source:[5]
- Prostate, ovary, liver, and esophagus cancer
- Hormone-related polycystic ovary syndrome
- Amyloid-related Alzheimer's
- Prion Diseases
