SH2B2

SH2B2
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1Q2H
Identifiers
Aliases	SH2B2, APS, SH2B adaptor protein 2
External IDs	OMIM: 605300; MGI: 1345171; HomoloGene: 10309; GeneCards: SH2B2; OMA:SH2B2 - orthologs
Gene location (Human)
Chr.	Chromosome 7 (human)
End	102,321,711 bp
Gene location (Mouse)
Chr.	Chromosome 5 (mouse)
End	136,275,410 bp
RNA expression pattern
	Top expressed in
	triceps brachii muscle; ; Skeletal muscle tissue of biceps brachii; ; muscle of thigh; ; vastus lateralis muscle; ; renal medulla; ; muscle of trunk; ; Skeletal muscle tissue of rectus abdominis; ; thoracic diaphragm; ; tibialis anterior muscle; ; body of tongue;
	Top expressed in
	brown adipose tissue; ; granulocyte; ; white adipose tissue; ; tunica adventitia of aorta; ; spermatocyte; ; ganglionic eminence; ; internal carotid artery; ; gastrula; ; tail of embryo; ; placenta;
	More reference expression data
	n/a
Gene ontology
Molecular function	JAK pathway signal transduction adaptor activity; protein binding; signaling adaptor activity; transmembrane receptor protein tyrosine kinase adaptor activity; identical protein binding;
Cellular component	cytoplasm; cytosol; plasma membrane; membrane; stress fiber; ruffle; actin filament;
Biological process	insulin receptor signaling pathway; blood coagulation; signal transduction; regulation of receptor signaling pathway via JAK-STAT; positive regulation of signal transduction; intracellular signal transduction; B-1 B cell homeostasis; nervous system development; cytokine-mediated signaling pathway; regulation of metabolic process; actin cytoskeleton organization; regulation of Ras protein signal transduction; regulation of immune response; antigen receptor-mediated signaling pathway; brown fat cell differentiation;
	Sources:Amigo / QuickGO
Orthologs
	10603
	23921
	ENSG00000160999
	ENSMUSG00000005057
	O14492
	Q9JID9
	NM_020979; NM_001359228; NM_001359229; NM_001359230; NM_001359231
	NM_018825; NM_001302938; NM_001302939
	NP_066189; NP_001346157; NP_001346158; NP_001346159; NP_001346160
	NP_001289867; NP_001289868; NP_061295
	Wikidata
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