SH3BP4

SH3 domain-binding protein 4 is a protein that in humans is encoded by the SH3BP4 gene.^[5][6]

AliasesSH3BP4, BOG25, TTP, SH3 domain binding protein 4

External IDsOMIM: 605611; MGI: 2138297; HomoloGene: 8726; GeneCards: SH3BP4; OMA:SH3BP4 - orthologs

Chr.Chromosome 2 (human)^[1]

End235,055,714 bp^[1]

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SH3BP4
Identifiers
Aliases	SH3BP4, BOG25, TTP, SH3 domain binding protein 4
External IDs	OMIM: 605611; MGI: 2138297; HomoloGene: 8726; GeneCards: SH3BP4; OMA:SH3BP4 - orthologs
Gene location (Human) Chr. Chromosome 2 (human)[1] Band 2q37.2 Start 234,952,017 bp[1] End 235,055,714 bp[1]
Gene location (Mouse) Chr. Chromosome 1 (mouse)[2] Band 1|1 D Start 88,998,137 bp[2] End 89,082,790 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in parotid gland trachea mucosa of paranasal sinus renal medulla germinal epithelium nasal epithelium caput epididymis Epithelium of choroid plexus tibia epithelium of lactiferous gland Top expressed in lacrimal gland molar parotid gland maxillary prominence seminal vesicula mandibular prominence ascending aorta vestibular membrane of cochlear duct somite lumbar spinal ganglion More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding identical protein binding GDP-dissociation inhibitor activity Cellular component cytoplasm membrane clathrin-coated pit cytoplasmic vesicle extracellular exosome nucleus clathrin-coated vesicle Biological process cellular response to amino acid stimulus protein localization to lysosome negative regulation of GTPase activity regulation of catalytic activity endocytosis negative regulation of cell growth positive regulation of autophagy amino acid import negative regulation of cell population proliferation negative regulation of TOR signaling Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 23677 98402 Ensembl ENSG00000130147 ENSMUSG00000036206 UniProt Q9P0V3 Q921I6 RefSeq (mRNA) NM_014521 NM_133816 RefSeq (protein) NP_055336 NP_001358231 NP_001358232 NP_001358233 NP_001358234 NP_001358235 NP_598577 Location (UCSC) Chr 2: 234.95 – 235.06 Mb Chr 1: 89 – 89.08 Mb PubMed search [3] [4]
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This gene encodes a protein with 3 Asn-Pro-Phe (NPF) motifs, an SH3 domain, a PXXP motif, a bipartite nuclear targeting signal, and a tyrosine phosphorylation site. This protein is involved in cargo-specific control of clathrin-mediated endocytosis, specifically controlling the internalization of a specific protein receptor.^[6]