SH3KBP1

Protein-coding gene in the species Homo sapiens From Wikipedia, the free encyclopedia

SH3 domain-containing kinase-binding protein 1 (synonyms - CIN85[5], in rodents - Ruk[6]) is an adaptor protein that in humans is encoded by the SH3KBP1 gene.[7][8]

PDBOrtholog search: PDBe RCSB
AliasesSH3KBP1, CD2BP3, CIN85, GIG10, HSB-1, HSB1, MIG18, SH3 domain containing kinase binding protein 1, IMD61, AGMX2
External IDsOMIM: 300374; MGI: 1889583; HomoloGene: 10971; GeneCards: SH3KBP1; OMA:SH3KBP1 - orthologs
Chr.X chromosome (human)[1]
Quick facts Available structures, PDB ...
SH3KBP1
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesSH3KBP1, CD2BP3, CIN85, GIG10, HSB-1, HSB1, MIG18, SH3 domain containing kinase binding protein 1, IMD61, AGMX2
External IDsOMIM: 300374; MGI: 1889583; HomoloGene: 10971; GeneCards: SH3KBP1; OMA:SH3KBP1 - orthologs
Orthologs
SpeciesHumanMouse
Entrez

30011

58194

Ensembl

ENSG00000147010

ENSMUSG00000040990

UniProt

Q96B97
Q5JPT2

Q8R550

RefSeq (mRNA)
RefSeq (protein)
Location (UCSC)Chr X: 19.53 – 19.89 MbChr X: 158.41 – 158.76 Mb
PubMed search[3][4]
Wikidata
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Function

CBL (MIM 165360) constitutively interacts with SH3 domain-containing proteins and, upon tyrosine phosphorylation, with SH2 domain-containing proteins. The SH3KBP1 gene encodes an 85-kD CBL-interacting protein that enhances tumor necrosis factor (MIM 191160)-mediated apoptotic cell death (Narita et al., 2001).[supplied by OMIM][9]

Interactions

SH3KBP1 has been shown to interact with B-cell linker,[10] Grb2,[11][12] SH3GLB2,[13][14] SH3GL3,[13] SH3GL2,[14] BCAR1,[10] Epidermal growth factor receptor,[14][15] CBLB,[15] Cbl gene,[10][12][13][14][15] SOS1,[10] CRK[10] and PAK2.[16]

References

Further reading

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